MR demonstration of partial lesions of the lateral geniculate body and its functional intra-nuclear topography
MR demonstration of partial lesions of the lateral geniculate body and its functional intra-nuclear topography
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DOI：
10.1016/j.clineuro.2003.08.002
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发表时间：
2003-12-01
影响因子：
1.9
通讯作者：
Yamaura, A
中科院分区：
文献类型：
--
作者：
Saeki, N;Fujimoto, N;Yamaura, A
两个罕见的情况下，部分病变的外侧膝状体（LGB）可能是由于缺血表现在高分辨率磁共振成像。一位62岁女性（病例1）在Goldmann视野检查中表现为左半球上级象限盲。重T2加权磁共振成像显示局限性病变的外侧部分的LGB。视野缺损为黄斑区和水平子午线保留，持续9年。一位49岁女性（病例2）在Humphrey自动视野检查中突然出现左侧水平扇形盲，T2加权像显示病变位于右侧LGB的更内侧部分。基于动物实验的电生理学研究，起源于下、中央和上级视网膜的轴突基本上分别位于LGB的外侧、中央和内侧，并且该观察结果已应用于人类。这项研究的放射学显示，一个离散的外侧病变的LGB产生homperous上象限盲的情况下，1，而一个更位于中间的病变产生homperous sectoranopia的情况下，2，并揭示了轴突起源于下视网膜位于更外侧比中央视网膜在人类LGB。(C)2003 Elsevier B.V.保留所有权利。
Two rare cases with a partial lesion of the lateral geniculate body (LGB) presumably due to ischemia are demonstrated on high resolution MR imaging. A 62-year-old woman (case 1) presented with left homonymous superior quadrantanopia on Goldmann perimetry. Heavily T2 weighted MR images showed a localized lesion at the lateral portion of the LGB. The visual field defect was macular and horizontal meridian sparing and persisted for 9 years. A 49-year-old woman (case 2) presented with a sudden onset of left homonymous horizontal sectoranopia on Humphrey automated perimetry and heavily T2 weighted images demonstrated a lesion localized at the more medial part of the right LGB. Axons originating from inferior, central and superior retina are essentially located laterally, centrally and medially, respectively, in the LGB, based on the electrophysiological studies of animal experiments and this observation has been applied to humans. This study radiologically shows that a discrete lateral lesion of the LGB produced homonymous upper quadrantanopia in case 1, whereas a more medially located lesion produced homonymous sectoranopia in case 2, and reveals that the axons originating from inferior retina are located more laterally than those from central retina in the human LGB. (C) 2003 Elsevier B.V. All rights reserved.