Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers
Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers
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DOI：
10.1038/79910
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发表时间：
2000-10-01
影响因子：
25
通讯作者：
Joëls, M
中科院分区：
文献类型：
--
作者：
Karst, H;Karten, YJG;Joëls, M
压力后肾上腺会分泌大量的糖皮质激素。在大脑中，这些应激激素有效地调节离子电流，单胺能传递，突触可塑性和细胞活力1，2，3，最值得注意的是在皮质类固醇受体高度富集的海马4。在这里，我们表明，至少有一些这些行动需要糖皮质激素受体（GR）同源二聚体的DNA结合。
Glucocorticoids are secreted from the adrenal gland in very high amounts after stress. In the brain, these stress hormones potently modulate ionic currents, monoaminergic transmission, synaptic plasticity and cellular viability 1, 2, 3, most notably in the hippocampus where corticosteroid receptors are highly enriched 4. Here we show that at least some of these actions require DNA binding of glucocorticoid receptor (GR) homodimers.