T25: A simplified carcinogenic potency index: Description of the system and study of correlations between carcinogenic potency and species/site specificity and mutagenicity
T25: A simplified carcinogenic potency index: Description of the system and study of correlations between carcinogenic potency and species/site specificity and mutagenicity
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DOI：
10.1111/j.1600-0773.1997.tb01973.x
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发表时间：
1997-06-01
期刊：
影响因子：
--
通讯作者：
Tennant, RW
中科院分区：
文献类型：
--
作者：
Dybing, E;Sanner, T;Tennant, RW
一个简化的致癌效力指数，T25，建议作为一个实用的方法列入致癌物分类系统的效力考虑。T25是在该种属的标准寿命内，在校正自发发生率后，在特定组织部位给予25%动物谣言的慢性日剂量（mg/kg体重）。一组113种美国国家癌症研究所/国家毒理学计划（NC/NTP）致癌物的计算T25值显示出良好的相关性（相关系数0.96，P
A simplified carcinogenic potency index, the T25, is proposed as a practical method for the inclusion of potency considerations in carcinogen classification systems. The T25 is the chronic daily dose in mg per kg bodyweight which will give 25% of the animals rumours at a specific tissue site, after correction for spontaneous incidence, within the standard life span of that species. Calculated T25 values of a set of 113 US National Cancer Institute/National Toxicology Program (NC/NTP) carcinogens showed excellent correlation (correlation coefficient 0.96, P