Results of common laboratory tests in solvent-exposed workers
Results of common laboratory tests in solvent-exposed workers
复制标题
DOI：
10.1007/s00420-003-0476-z
复制
发表时间：
2004-01-01
影响因子：
3
通讯作者：
Taskinen, H
中科院分区：
文献类型：
--
作者：
Kaukiainen, A;Vehmas, T;Taskinen, H
目标。在临床实践中，筛查和识别与长期、低水平溶剂接触相关的职业性肝脏或其他器官系统损伤是很困难的。我们研究了使用常见实验室测试并结合详细的暴露史的可行性。方法。通过根据年龄、饮酒量、性别和体重指数 (BMI) 进行调整的回归模型研究了实验室测试与有机溶剂暴露之间的关系。受试者为 29 名接触溶剂的工人和 19 名参考对象。实验室检查包括血清丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、γ-谷氨酰转移酶（GGT）、碳水化合物缺乏转铁蛋白（CDT）、碱性磷酸酶（ALP）、肌酐、胆固醇、HDL-胆固醇、甘油三酯、血糖以及总胆红素和结合胆红素。肝炎血清学阳性、全身性疾病或已知对肝脏有影响的药物以及当前妊娠是排除标准。确定了每个受试者的主要暴露情况。记录当前溶剂暴露状态、过去 3 个月的暴露情况、过去 5 年和 10 年的暴露情况以及总生命周期暴露情况。结果。 AST (P=0.0031)、ALT (P=0.0015) 和胆固醇 (P=0.0110) 与过去 5 年累积溶剂暴露、当前暴露总胆红素 (P=0.0380) 和过去 5 年暴露葡萄糖 (P
Objectives. The screening and identification of occupational liver or other organ-system injury related to long-term, low-level solvent exposure are difficult in clinical practice. We studied the feasibility of the use of common laboratory tests combined with a detailed exposure history. Methods. The relationships between laboratory tests and exposure to organic solvents were studied in regression modelling adjusted to age, alcohol consumption, gender and body mass index (BMI). The subjects were 29 solvent-exposed workers and 19 referents. Laboratory tests included serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), carbohydrate-deficient transferrin (CDT), alkaline phosphatase (ALP), creatinine, cholesterol, HDL-cholesterol, triglycerides, blood glucose and total and conjugated bilirubin. Positive hepatitis serology, systemic diseases or medications with known hepatic effects and current pregnancy were exclusion criteria. The main exposures of each subject were identified. Current solvent exposure status, exposure during the past 3 months, exposure during the past 5 and 10 years, and total life-time exposure were recorded. Results. AST (P=0.0031), ALT (P=0.0015) and cholesterol (P=0.0110) correlated positively with cumulative solvent exposure in the past 5 years, total bilirubin with current exposure (P=0.0380), and glucose with exposure in the past 5 (P