Alcohol Intake and Risk of Ischemic and Haemorrhagic Stroke: Results from a Mendelian Randomisation Study
Alcohol Intake and Risk of Ischemic and Haemorrhagic Stroke: Results from a Mendelian Randomisation Study
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DOI：
10.5853/jos.2017.01466
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发表时间：
2018-05-01
影响因子：
8.2
通讯作者：
Tolstrup, Janne S.
中科院分区：
文献类型：
--
作者：
Christensen, Anne L.;Nordestgaard, Borge G.;Tolstrup, Janne S.
背景和目的为了检验酒精摄入量是否与缺血性和出血性strok.Methods的风险相关，我们使用了哥本哈根城市心脏研究1991年至1994年和2001年至2003年的数据，以及哥本哈根一般人群研究2003年至2012年（n=78,546）。作为衡量酒精暴露，自我报告的消费和酒精代谢基因（酒精脱氢酶ADH 1B和ADH 1C）的遗传变异作为工具变量。中风的诊断是从一个有效的医院registration.Results后续2,535例缺血性和出血性中风发生。低和中等酒精摄入量（每周1至20杯）与中风风险降低有关。与饮酒相比，每周饮酒1 - 6、7 - 13和14 - 20次的风险比分别为0.84（95%置信区间[CI]，0.76 - 0.92）、0.83（95% CI，0.73 - 0.94）和0.84（95% CI，0.73 - 0.97）。
Background and Purpose To test whether alcohol intake, both observational and estimated by genetic instruments, is associated with risk of ischemic and haemorrhagic stroke.Methods We used data from the Copenhagen City Heart Study 1991 to 1994 and 2001 to 2003, and the Copenhagen General Population Study 2003 to 2012 (n=78,546). As measure of alcohol exposure, self-reported consumption and genetic variation in alcohol metabolizing genes (alcohol dehydrogenase ADH1B and ADH1C) as instrumental variables were used. Stroke diagnoses were obtained from a validated hospital register.Results During follow-up 2,535 cases of ischemic and haemorrhagic stroke occurred. Low and moderate alcohol intake (1 to 20 drinks/week) was associated with reduced risk of stroke. The hazard ratios associated with drinking 1 to 6, 7 to 13, and 14 to 20 drinks/week were 0.84 (95% confidence interval [Cl], 0.76 to 0.92), 0.83 (95% CI, 0.73 to 0.94), and 0.84 (95% CI, 0.73 to 0.97), respectively, compared with drinking