ALTERATION OF MECHANICAL PERFORMANCE OF VENTRICLE BY INTRAAORTIC BALLOON COUNTERPULSATION
ALTERATION OF MECHANICAL PERFORMANCE OF VENTRICLE BY INTRAAORTIC BALLOON COUNTERPULSATION
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DOI：
10.1016/0002-9149(70)90593-x
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发表时间：
1970-01-01
影响因子：
2.8
通讯作者：
SONNENBLICK, E
中科院分区：
文献类型：
--
作者：
URSCHEL, CW;EBER, L;SONNENBLICK, E
主动脉内球囊反搏已被证明可以降低犬急性心肌梗死的即刻死亡率。先前的研究强调了由舒张压升高引起的冠状动脉血流量绝对或相对增加的重要性。本研究旨在阐明反搏的收缩压降低特性在增加心输出量中的作用。11只狗被研究，除反搏外，没有干预。左室压峰值从138±7下降到116±6毫米汞柱(P<；0.01)的同时，平均舒张压从111±5上升到124±4毫米汞柱。由于射血阻抗降低，主动脉峰值流量、每搏输出量和心输出量增加了15%。在6只结扎左冠状动脉前降支后继发急性心肌梗死的犬中，血流动力学测量有平行但不明显的变化。从峰值流量、每搏输出量和输出量来评估心室的外部性能时，与射血阻抗成反比。由于对衰竭心脏的有效辅助必须导致外部表现的改善，因此不能低估适当降低收缩阻抗的重要性。
Intraaortic balloon counterpulsation has been shown to reduce the immediate mortality due to acute myocardial infarction in dogs. Previous studies have emphasized the importance of the absolute or relative increases in coronary blood flow that result from augmentation of diastolic aortic pressure. This study was designed to clarify the role of the decreased systolic pressure characteristic of counterpulsation in increasing the cardiac output.Eleven dogs were studied without intervention except for counterpulsation. A decrease in peak left ventricular pressure from 138 ± 7 to 116 ± 6 mmHg(P< 0.01) was paralleled by an increase in mean diastolic aortic pressure from 111 ± 5 to 124 ± 4 mmHg. As a result of the decreased impedance to ejection, peak aortic flow, stroke volume and cardiac output increased by 15 percent. In 6 dogs studied after acute myocardial infarction secondary to ligation of the left anterior descending coronary artery, there were parallel but less marked changes in the hemodynamic measurements.The external performance of the ventricle when evaluated in terms of peak flow, stroke volume and output was an inverse function of the impedance to ejection. Since effective assistance to the failing heart must result in increased external performance, the importance of adequate reduction of systolic impedance must not be underestimated.