Prenatal methylmercury exposure as a cardiovascular risk factor at seven years of age.
Prenatal methylmercury exposure as a cardiovascular risk factor at seven years of age.
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DOI：
10.1097/00001648-199907000-00006
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发表时间：
1999-07
期刊：
影响因子：
5.4
通讯作者：
Nicolina Sørensen;K. Murata;E. Budtz-Jørgensen;P. Weihe;P. Grandjean
中科院分区：
文献类型：
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作者：
Nicolina Sørensen;K. Murata;E. Budtz-Jørgensen;P. Weihe;P. Grandjean
儿童期血压是日后高血压风险的重要决定因素，甲基汞暴露是一个潜在的环境风险因素。对来自法罗群岛的1000名儿童的出生队列进行了产前甲基汞暴露检查，并在7岁时确定了血压、心率和心率变异性。调整体重后，当脐带血汞浓度从1微克/升增加到10微克/升时，舒张压和收缩压分别增加13.9 mmHg[95%置信限(CL) = 7.4, 20.4]和14.6 mmHg （95% CL = 8.3, 20.8）。超过这一水平，即相当于目前的暴露极限，没有进一步增加。出生体重起着调节作用，对出生体重较低的儿童，汞的影响更大。在男孩中，心率变异性随着汞暴露的增加而下降，特别是从1至10微克/升脐带血，变异性降低47% （95% CL = 14%, 68%）。这些发现表明，产前甲基汞暴露可能影响心血管内稳态的发展。
Blood pressure in childhood is an important determinant of hypertension risk later in life, and methylmercury exposure is a potential environmental risk factor. A birth cohort of 1,000 children from the Faroe Islands was examined for prenatal exposure to methylmercury, and at age 7 years, blood pressure, heart rate, and heart rate variability were determined. After adjustment for body weight, diastolic and systolic blood pressure increased by 13.9 mmHg [95% confidence limits (CL) = 7.4, 20.4] and 14.6 mmHg (95% CL = 8.3, 20.8), respectively, when cord blood mercury concentrations increased from 1 to 10 microg/liter cord blood. Above this level, which corresponds to a current exposure limit, no further increase was seen. Birth weight acted as a modifier, with the mercury effect being stronger in children with lower birth weights. In boys, heart rate variability decreased with increasing mercury exposures, particularly from 1 to 10 microg/liter cord blood, at which the variability was reduced by 47% (95% CL = 14%, 68%). These findings suggest that prenatal exposure to methylmercury may affect the development of cardiovascular homeostasis.