Prelimbic and Infralimbic Prefrontal Regulation of Active and Inhibitory Avoidance and Reward-Seeking
Prelimbic and Infralimbic Prefrontal Regulation of Active and Inhibitory Avoidance and Reward-Seeking
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DOI：
10.1523/jneurosci.0414-20.2020
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发表时间：
2020-06-10
影响因子：
5.3
通讯作者：
Floresco, Stan B.
中科院分区：
文献类型：
--
作者：
Capuzzo, Giulia;Floresco, Stan B.
灵活地启动或抑制行动以避免令人厌恶的事件对生存至关重要。内侧前额叶皮层（mPFC）的边缘前区（PL）和边缘下区（IL）参与了回避和奖赏寻求的不同方面，但在厌恶性情境中，它们各自在煽动和抑制行为中的作用仍有待澄清。我们研究了mPFC参与不同形式的回避在不同的线索回避-按回避任务训练有素的大鼠。主动/抑制回避需要灵活的听觉线索之间的歧视信号足电击，可以避免作出或扣留仪器的反应。在一个简单的主动回避任务中，当按下杠杆可以避免电击时，会有一个单一的提示。PL失活破坏了主动回避，但不抑制性回避的歧视性任务，而对单一线索回避没有影响。相比之下，IL失活广泛损害主动和抑制性回避。相反，在一个线索的食欲去/不去的任务，IL和PL失活受损的抑制，但不主动寻求奖励，后者的效果是截然相反的，观察到的回避任务。这些研究结果强调了复杂的方式，不同的mPFC区域在启动或抑制行动，以避免令人厌恶的结果或获得奖励的服务。IL促进主动回避，但抑制不适当的行动，在食欲和厌恶的情况下。与此相反，语境效价起着至关重要的作用，在PL是如何招募发起或抑制行动，这可能涉及到灵活协商反应或动机冲突，并推翻优势行为所需的认知控制的程度。
Flexible initiation or suppression of actions to avoid aversive events is crucial for survival. The prelimbic (PL) and infralimbic (IL) regions of the medial prefrontal cortex (mPFC) have been implicated in different aspects of avoidance and reward-seeking, but their respective contribution in instigating versus suppressing actions in aversive contexts remains to be clarified. We examined mPFC involvement in different forms of avoidance in rats well trained on different cued lever-press avoidance tasks. Active/inhibitory avoidance required flexible discrimination between auditory cues signaling foot-shock could be avoided by making or withholding instrumental responses. On a simpler active avoidance task, a single cue signaled when a lever press would avoid shock. PL inactivation disrupted active but not inhibitory avoidance on the discriminative task while having no effect on single-cued avoidance. In comparison, IL inactivation broadly impaired active and inhibitory avoidance. Conversely, on a cued appetitive go/no-go task, both IL and PL inactivation impaired inhibitory but not active reward-seeking, the latter effect being diametrically opposite to that observed on the avoidance task. These findings highlight the complex manner in which different mPFC regions aid in initiating or inhibiting actions in the service of avoiding aversive outcomes or obtaining rewarding ones. IL facilitates active avoidance but suppress inappropriate actions in appetitive and aversive contexts. In contrast, contextual valence plays a critical role in how the PL is recruited in initiating or suppressing actions, which may relate to the degree of cognitive control required to flexibly negotiate response or motivational conflicts and override prepotent behaviors.