Radical Synthesis of Guanidines from N-Acyl Cyanamides
Radical Synthesis of Guanidines from N-Acyl Cyanamides
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DOI：
10.1002/anie.200907237
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发表时间：
2010-01-01
影响因子：
16.6
通讯作者：
Lacote, Emmanuel
中科院分区：
文献类型：
--
作者：
Larraufie, Marie-Helene;Ollivier, Cyril;Lacote, Emmanuel
在优化的条件下，通过自由基多米诺反应，将芳香族N-酰基氰胺和N-烯酰基氰胺缓慢加成为双环、三环和四环胍。
Aromatic N-acyl cyanamides as well as N-enoyl cyanamides are converted by slow addition of Bu 3 SnH and AIBN into bi-, tri and tetracyclic guanidines via a radical domino process under optimized conditions.