Photoactivation of gold nanoparticles for glioma treatment
Photoactivation of gold nanoparticles for glioma treatment
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DOI：
10.1016/j.nano.2013.04.007
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发表时间：
2013-10-01
影响因子：
5.4
通讯作者：
Elleaume, Helene
中科院分区：
文献类型：
--
作者：
Bobyk, Laure;Edouard, Magali;Elleaume, Helene
在患有神经胶质瘤的大鼠身上体外和体内评估了具有低能量辐射（88 keV）的金纳米颗粒（AuNP）的放射增敏功效。在体外，在 AuNP（直径 1.9 和 15 nm）存在下，F98 神经胶质瘤细胞经同步加速器辐射后，通过克隆形成测定测量了显着的剂量增强因子。在体内，1.9 nm 纳米颗粒在脑胶质瘤大鼠脑内递送后被发现具有毒性，无论使用相同浓度 (50 mg/mL) 的 15 nm 纳米颗粒是否没有观察到毒性。金光活化的治疗效果通过在脑内输注 AuNPs 后对动物进行照射来确定。与单独接受放射治疗的大鼠相比，接受联合治疗（AuNP：50 mg/mL，15 Gy）的大鼠的存活率显着增加。总之，这种实验方法是有前途的，预计将进行进一步的研究以提高其治疗效果。 (C) 2013 Elsevier Inc. 保留所有权利。
Radiosensitization efficacy of gold nanoparticles (AuNPs) with low energy radiations (88 keV) was evaluated in vitro and in vivo on rats bearing glioma. In vitro, a significant dose-enhancement factor was measured by clonogenic assays after irradiation with synchrotron radiation of F98 glioma cells in presence of AuNPs (1.9 and 15 nm in diameter). In vivo, 1.9 nm nanoparticles were found to be toxic following intracerebral delivery in rats bearing glioma, whether no toxicity was observed using 15 nm nanoparticles at the same concentration (50 mg/mL). The therapeutic efficacy of gold photoactivation was determined by irradiating the animals after intracerebral infusion of AuNPs. Survival of rats that had received the combination of treatments (AuNPs: 50 mg/mL, 15 Gy) was significantly increased in comparison with the survival of rats that had received irradiation alone. In conclusion, this experimental approach is promising and further studies are foreseen for improving its therapeutic efficacy. (C) 2013 Elsevier Inc. All rights reserved.