SHIGA-LIKE TOXIN-CONVERTING PHAGES FROM ESCHERICHIA-COLI STRAINS THAT CAUSE HEMORRHAGIC COLITIS OR INFANTILE DIARRHEA
SHIGA-LIKE TOXIN-CONVERTING PHAGES FROM ESCHERICHIA-COLI STRAINS THAT CAUSE HEMORRHAGIC COLITIS OR INFANTILE DIARRHEA
复制标题
DOI：
10.1126/science.6387911
复制
发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
FORMAL, SB
中科院分区：
文献类型：
--
作者：
OBRIEN, AD;NEWLAND, JW;FORMAL, SB
E.大肠杆菌K-12经两种噬菌体溶原化后，获得了产生高滴度志贺样毒素的能力。大肠杆菌0157：H7菌株引起出血性结肠炎。其中一个噬菌体和另一个来自E.与婴幼儿腹泻相关的大肠杆菌026分离株在形态学、病毒粒子多肽、DNA限制性片段、溶原性免疫和热稳定性方面密切相关，但宿主范围不同。目前，这些志贺样毒素是志贺样毒素转化酶家族中最具特征的代表。
E. coli K-12 acquired the ability to produce a high titer of Shiga-like toxin after lysogenization by either of 2 different bacteriophages isolated from a highly toxinogenic E. coli 0157:H7 strain that causes hemorrhagic colitis. One of these phages and another Shiga-like toxin-converting phage from an E. coli 026 isolate associated with infantile diarrhea were closely related in terms of morphology, virion polypeptides, DNA restriction fragments, lysogenic immunity and heat stability, although a difference in host range was noted. These phages are currently the best-characterized representatives from a broader family of Shiga-like toxin-converting phages.