Dynamic interplay between bone and multiple myeloma: emerging roles of the osteoblast.
Dynamic interplay between bone and multiple myeloma: emerging roles of the osteoblast.
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DOI：
10.1016/j.bone.2015.02.021
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发表时间：
2015-06
期刊：
影响因子：
4.1
通讯作者：
Ghobrial IM
中科院分区：
文献类型：
--
作者：
Reagan MR;Liaw L;Rosen CJ;Ghobrial IM
多发性骨髓瘤是一种B细胞恶性肿瘤，其特征在于浆细胞的持续增殖。多发性骨髓瘤引起溶骨性病变和骨折，由于成骨细胞减少和骨细胞活性增加而不能愈合。然而，成骨细胞和骨髓瘤细胞之间的确切关系仍然难以捉摸。了解这些动态骨形成细胞和骨髓瘤细胞之间的相互作用对于了解溶骨性病变如何形成和持续以及肿瘤如何在骨髓内生长至关重要。本文综述了成骨细胞在多发性骨髓瘤进展中的作用及其与溶骨性病变的关系的基础和转化研究。重要的是，目前的挑战，在体外研究探索骨髓瘤细胞的直接成骨细胞的影响，并在理解骨髓瘤进展中的成骨细胞的作用的差距划定。最后，列举了骨合成代谢治疗（即任何诱导成骨细胞数量或活性增加的治疗）在骨髓瘤治疗中的成功和挑战。我们的目标是阐明成骨细胞可能促进多发性骨髓瘤疾病进展和骨质溶解的新机制，以更好地指导研究工作。最终，我们希望这可能为多发性骨髓瘤的发病机制和治疗提供新的方法路线图，特别关注成骨细胞。
Multiple myeloma is a B-cell malignancy characterized by the unrelenting proliferation of plasma cells. Multiple myeloma causes osteolytic lesions and fractures that do not heal due to decreased osteoblastic and increased osteoclastic activity. However, the exact relationship between osteoblasts and myeloma cells remains elusive. Understanding the interactions between these dynamic bone-forming cells and myeloma cells is crucial to understanding how osteolytic lesions form and persist, and how tumors grow within the bone marrow. This review provides a comprehensive overview of basic and translational research focused on the role of osteoblasts in multiple myeloma progression and their relationship to osteolytic lesions. Importantly, current challenges for in vitro studies exploring direct osteoblastic effects on myeloma cells, and gaps in understanding the role of the osteoblast in myeloma progression are delineated. Finally, successes and challenges in myeloma treatment with osteoanabolic therapy (i.e. any treatment that induces increased osteoblastic number or activity) are enumerated. Our goal is to illuminate novel mechanisms by which osteoblasts may contribute to multiple myeloma disease progression and osteolysis to better direct research efforts. Ultimately, we hope this may provide a roadmap for new approaches to the pathogenesis and treatment of multiple myeloma with a particular focus on the osteoblast.