Statistical analysis of the Ames Salmonella/microsome test.
Statistical analysis of the Ames Salmonella/microsome test.
复制标题
艾姆斯沙门氏菌/微粒体测试的统计分析。
DOI：
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发表时间：
1981
影响因子：
11.1
通讯作者：
E. Zeiger
中科院分区：
文献类型：
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作者：
B. Margolin;N. Kaplan;E. Zeiger
构建了一系列用于分析艾姆斯沙门氏菌/微粒体试验数据的统计模型，该模型将突变和毒性视为竞争风险，并允许超泊松变异性。这些模型具有可用作致突变指数的参数，因为其近似于针对毒性调整的剂量-反应曲线在零剂量时的斜率。第二个参数量化了平板间的变异性，并有助于研究影响内部检测重现性的因素。还讨论了异常平板计数的检测。该方法用沙门氏菌测试的数据来说明。
A family of statistical models for analysis of Ames Salmonella/microsome test data is constructed that considers mutation and toxicity as competing risks and allows hyper-Poisson variability. These models have a parameter than can be employed as a mutagenic index because it approximates the slope at zero dose of a dose-response curve adjusted for toxicity. A second parameter quantifies plate-to-plate variability and lends itself to the study of factors affecting internal test reproducibility. The detection of aberrant plate counts is also addressed. This methodology is illustrated with data from a Salmonella test.