Altered Structural Connectome in Temporal Lobe Epilepsy
Altered Structural Connectome in Temporal Lobe Epilepsy
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DOI：
10.1148/radiol.13131044
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发表时间：
2014-03-01
期刊：
影响因子：
19.7
通讯作者：
Stufflebeam, Steven M.
中科院分区：
文献类型：
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作者：
DeSalvo, Matthew N.;Douw, Linda;Stufflebeam, Steven M.
目的：研究左颞叶癫痫（TLE）患者和健康对照组全脑结构连接体的差异。材料和方法：本研究经机构审查委员会批准，所有个体均签署知情同意书。在24例左侧TLE患者和24例健康对照者中分析了60个方向的扩散张量成像和磁化准备的快速采集梯度回波（MP-MRI）磁共振成像体积。MP-MRI体积被分割成跨越整个大脑的1015个感兴趣区域（ROI）。在体素张量计算后进行确定性白色物质纤维束成像。加权结构连接矩阵是通过使用感兴趣区之间的连接纤维的成对密度生成的。结果：TLE患者的神经网络连通性降低了22%~ 45%（P
Purpose: To study differences in the whole-brain structural connectomes of patients with left temporal lobe epilepsy (TLE) and healthy control subjects.Materials and Methods: This study was approved by the institutional review board, and all individuals gave signed informed consent. Sixty-direction diffusion-tensor imaging and magnetization-prepared rapid acquisition gradient-echo (MP-RAGE) magnetic resonance imaging volumes were analyzed in 24 patients with left TLE and in 24 healthy control subjects. MP-RAGE volumes were segmented into 1015 regions of interest (ROIs) spanning the entire brain. Deterministic white matter tractography was performed after voxelwise tensor calculation. Weighted structural connectivity matrices were generated by using the pairwise density of connecting fibers between ROIs. Graph theoretical measures of connectivity networks were compared between groups by using linear models with permutation testing.Results: Patients with TLE had 22%-45% reduced (P