Vitamin D-associated genetic variation and risk of breast cancer in the breast and prostate cancer cohort consortium (BPC3).
Vitamin D-associated genetic variation and risk of breast cancer in the breast and prostate cancer cohort consortium (BPC3).
复制标题
维生素D与乳腺癌和前列腺癌队列联盟（BPC3）中乳腺癌相关的遗传变异和乳腺癌风险。
DOI：
10.1158/1055-9965.epi-14-1127
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Albanes D
中科院分区：
文献类型：
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作者：
Mondul AM;Shui IM;Yu K;Weinstein SJ;Tsilidis KK;Joshi AD;Agudo A;Berg CD;Black A;Buring JE;Chasman DI;Gaudet MM;Haiman C;Hankinson SE;Henderson BE;Hoover RN;Hunter DJ;Khaw KT;Kühn T;Kvaskoff M;Le Marchand L;Lindström S;McCullough ML;Overvad K;Peeters PH;Riboli E;Ridker PM;Stram DO;Sund M;Trichopoulos D;Tumino R;Weiderpass E;Willett W;Kraft P;Ziegler RG;Albanes D
最近的两项全基因组关联研究（GWAS）在四个基因中或附近发现了与循环25-羟基维生素D [25（OH）D]浓度相关的SNP。为了研究维生素D状态与乳腺癌之间的假设负相关关系，我们在一项大型汇总研究中研究了这些基因中的SNP与乳腺癌风险之间的关系，该研究包括来自6个队列的9，456例病例和10，816例对照。定位于先前与25（OH）D相关的四个基因（GC、CYP 24 A1、CYP 2 R1和DHCR 7）的SNP标记进行基因分型，并单独和作为4-SNP多基因评分进行检查。Logistic回归用于估计遗传变异与乳腺癌风险之间的关联。我们没有发现任何四个SNPs或其多基因评分与乳腺癌风险之间的关联。我们的研究结果不支持维生素D状态（如25（OH）D相关基因型所反映的）与乳腺癌风险之间的关联。这些发现可能有助于未来的荟萃分析和科学评论文章，并提供有关维生素D相关基因与乳腺癌之间关联的新数据。
Two recent genome-wide association studies (GWAS) identified SNPs related to circulating 25-hydroxyvitamin D [25(OH)D] concentration in or near four genes. To examine the hypothesized inverse relationship between vitamin D status and breast cancer, we studied the associations between SNPs in these genes and breast cancer risk in a large pooled study of 9,456 cases and 10,816 controls from six cohorts. SNP markers localized to each of four genes (GC, CYP24A1, CYP2R1, and DHCR7) previously associated with 25(OH)D were genotyped and examined both individually and as a 4-SNP polygenic score. Logistic regression was used to estimate the associations between the genetic variants and risk of breast cancer. We found no association between any of the four SNPs or their polygenic score and breast cancer risk. Our findings do not support an association between vitamin D status, as reflected by 25(OH)D-related genotypes, and breast cancer risk. These findings may contribute to future meta-analyses and scientific review articles, and provide new data about the association between vitamin D-related genes and breast cancer.