Mechanism of selective inhibition of human immunodeficiency virus by ingenol triacetate
Mechanism of selective inhibition of human immunodeficiency virus by ingenol triacetate
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DOI：
10.1128/aac.40.1.271
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发表时间：
1996-01-01
影响因子：
4.9
通讯作者：
Baba, M
中科院分区：
文献类型：
--
作者：
Fujiwara, M;Ijichi, K;Baba, M
巨大戟醇3,5,20 - 三乙酸酯（ITA）是巨大戟醇衍生物之一，是一种体外选择性抑制人免疫缺陷病毒（HIV）复制的抑制剂。ITA在0.051至0.65μM的浓度下可抑制HIV毒株在MT - 4细胞中的复制。该浓度比其细胞毒性阈值大约低10³倍。ITA的作用机制主要归因于抑制病毒对宿主细胞的吸附，但它不同于其他吸附抑制剂的抑制机制。
Ingenol 3,5,20-triacetate (ITA), one of the ingenol derivatives, is a selective inhibitor of human immunodeficiency virus (HIV) replication in vitro. ITA inhibited the replication of HIV strains in MT-4 cells at concentrations of 0.051 to 0.65 mu M. This concentration was approximately 10(3)-fold lower than its cytotoxic threshold. The mechanism of action of ITA is primarily attributed to the inhibition of viral adsorption to the host cells, but it is distinct from the mechanism of inhibition by other adsorption inhibitors.