Stability of high-frequency (600 Hz) components in human somatosensory evoked potentials under variation of stimulus rate -: evidence for a thalamic origin
Stability of high-frequency (600 Hz) components in human somatosensory evoked potentials under variation of stimulus rate -: evidence for a thalamic origin
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DOI：
10.1016/s1388-2457(99)00114-5
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发表时间：
1999-09-01
影响因子：
4.7
通讯作者：
Curio, G
中科院分区：
文献类型：
--
作者：
Gobbelé, R;Buchner, H;Curio, G
在人类正中神经体感诱发电位（SEP）的初级皮层反应（N20）上叠加的尖峰样高频（600 Hz）小波的发生器已被定位在解剖学上既接近初级体感手皮层和丘脑-皮层投射神经元的深轴突段。在这里，N20和600 Hz的突发组件功能分离，通过改变刺激率（1.5，3，6，9 Hz）。N20源振幅显着降低，在较高的刺激率。相比之下，600 Hz振荡的源振幅在所有刺激速率下保持稳定。这反映了不同的来源起源，确认突触后皮质内生成的N20组件，并提供了进一步的证据，为突触前起源的600 Hz的活动，如重复的神经元群体尖峰进行深，浅段的丘脑-皮质投射纤维。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
The generators of spike-like high-frequency (600 Hz) wavelets superimposed on the primary cortical response (N20) in human median nerve somatosensory evoked potentials (SEP) have been localized anatomically both close to the primary somatosensory hand cortex and in deep axon segments of thalamo-cortical projection neurons. Here, N20 and 600 Hz burst components were functionally dissociated by varying the stimulus rate (1.5, 3, 6, 9 Hz). The N20 source amplitudes were significantly reduced at the higher stimulus rates. In contrast, the source amplitudes of the 600 Hz oscillations remained stable across all stimulus rates. This reflects different source origins, confirming a postsynaptic intracortical generation of the N20 component and provides further evidence for a presynaptic origin of the 600 Hz activity like repetitive neuronal population spikes conducted in deep and superficial segments of thalamo-cortical projection fibers. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.