The epidemiology of neural tube defects: a review of dietary intake and related factors as etiologic agents.
The epidemiology of neural tube defects: a review of dietary intake and related factors as etiologic agents.
复制标题
神经管缺陷的流行病学：对饮食摄入和作为病因的相关因素的回顾。
DOI：
10.1093/oxfordjournals.aje.a115924
复制
发表时间：
1991
影响因子：
5
通讯作者：
Janerich,DT
中科院分区：
文献类型：
--
作者：
Slattery,ML;Janerich,DT
尽管目前正在努力阐明饮食摄入和/或补充剂使用在人类神经管缺陷发展中的作用，但尚未建立明确的关联。大多数研究都检查了受孕前或受孕后不久的饮食摄入/补充剂。然而，慢性营养不良状态可能会导致这些缺陷，而不是受孕时的急性缺乏。对于一些女性来说，膳食补充剂可能会克服慢性营养不良的影响，从而防止神经管缺陷的发生。由于迄今为止进行的研究的局限性，美国医学研究所最近的一份报告得出的结论是，缺乏证据支持围孕期使用多种维生素补充剂来预防神经管缺陷的建议。目前尚不清楚在受孕前或怀孕早期改善女性饮食质量或服用多种维生素补充剂是否可以降低婴儿患有神经管缺陷的风险。
Although efforts are currently under way to clarify the role of dietary intake and/or supplement use in the development of neural tube defects in man, clear associations have not yet been made. Most studies have examined dietary intake/supplements immediately prior to or shortly after conception. However, it is possible that a state of chronic malnutrition contributes to these defects rather than an acute deficiency near the time of conception. In some women, dietary supplementation may override the effects of chronic malnutrition, thus preventing neural tube defects from occurring. Because of the limitations of studies conducted to date, a recent report by the Institute of Medicine (USA) concluded that there is a lack of evidence supporting the recommendation that multivitamin supplements be used periconceptionally to prevent neural tube defects. It is not known if the improvement of the quality of a woman's diet or the taking of a multivitamin supplement either prior to conception or early in pregnancy can reduce the risk of having an infant with a neural tube defect.