Right inferior frontal gyrus damage is associated with impaired initiation of inhibitory control, but not its implementation.
Right inferior frontal gyrus damage is associated with impaired initiation of inhibitory control, but not its implementation.
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DOI：
10.7554/elife.79667
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发表时间：
2022-12-30
期刊：
影响因子：
7.7
通讯作者：
Wessel JR
中科院分区：
文献类型：
--
作者：
Choo Y;Matzke D;Bowren MD Jr;Tranel D;Wessel JR
抑制控制是人脑最重要的控制功能之一。我们对它的神经基础的理解大部分来自于开创性的工作，这些工作表明，右额下回（rIFG）的损伤会增加停止信号反应时间（SSRT），这是一个表达抑制控制速度的潜在变量。然而，最近的工作已经确定了SSRT方法的实质性局限性。值得注意的是，SSRT是混淆的触发故障：停止信号试验中，抑制控制从未启动。这些试验会增加SSRT，但通常表明注意力缺陷，而不是抑制缺陷。在这里，我们使用分层贝叶斯建模来识别人rIFG病变患者、非rIFG病变患者和健康对照中的停止信号触发失败。此外，我们测量头皮脑电图检测β爆发，抑制控制的神经生理指标。rIFG病变患者在触发失败试验中表现出超过5倍的增加，并且没有表现出典型的停止相关额叶β爆发的增加。然而，在确实发生这种β爆发的试验中，rIFG患者表现出典型的随后在感觉运动区上调β，表明一旦触发，他们实施抑制控制的能力保持不变。这些发现表明，rIFG在抑制控制中的作用必须从根本上重新解释。
Inhibitory control is one of the most important control functions in the human brain. Much of our understanding of its neural basis comes from seminal work showing that lesions to the right inferior frontal gyrus (rIFG) increase stop-signal reaction time (SSRT), a latent variable that expresses the speed of inhibitory control. However, recent work has identified substantial limitations of the SSRT method. Notably, SSRT is confounded by trigger failures: stop-signal trials in which inhibitory control was never initiated. Such trials inflate SSRT, but are typically indicative of attentional, rather than inhibitory deficits. Here, we used hierarchical Bayesian modeling to identify stop-signal trigger failures in human rIFG lesion patients, non-rIFG lesion patients, and healthy comparisons. Furthermore, we measured scalp-EEG to detect β-bursts, a neurophysiological index of inhibitory control. rIFG lesion patients showed a more than fivefold increase in trigger failure trials and did not exhibit the typical increase of stop-related frontal β-bursts. However, on trials in which such β-bursts did occur, rIFG patients showed the typical subsequent upregulation of β over sensorimotor areas, indicating that their ability to implement inhibitory control, once triggered, remains intact. These findings suggest that the role of rIFG in inhibitory control has to be fundamentally reinterpreted.