HOST-FINDING AND HOST RECOGNITION OF INFECTIVE ANCYLOSTOMA-CANINUM LARVAE
HOST-FINDING AND HOST RECOGNITION OF INFECTIVE ANCYLOSTOMA-CANINUM LARVAE
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DOI：
10.1016/0020-7519(91)90100-l
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发表时间：
1991-07-01
影响因子：
4
通讯作者：
HAAS, W
中科院分区：
文献类型：
--
作者：
GRANZER, M;HAAS, W
犬蛔虫幼虫对环境和宿主刺激作出反应，有四个寻找宿主的行为阶段。 (1) 蛇状运动是由温暖和基质的特定振动刺激的。 (2)挥动行为是被动转变为狗毛的先决条件。它受到热辐射以及气流中的二氧化碳含量、温暖和湿度的刺激。 (3)爬行方向：幼虫被0.04℃ mm-1微弱的温度梯度中的热量和狗亲水性皮肤表面提取物所吸引，但不被皮肤脂质或血清所吸引。 (4)通过热、狗亲水性皮肤组分和狗血清刺激对琼脂的渗透。血清的有效成分分子量在5000到30000之间，被蛋白酶消化后就失去了功效，被证明是一种蛋白质。狗的唾液、尿液、牛奶和各种纯狗血清成分均不会刺激渗透。犬曲霉幼虫能够反复穿透小鼠皮肤，但它们不会沿着先前穿透的幼虫在琼脂中的踪迹。
A. caninum larvae responded to environmental and host stimuli with four behavioral phases of host-finding. (1) Snake-like movement was stimulated by warmth and by defined vibrations of the substratum. (2) Waving behavior was a prerequisite for the passive change-over to dog hairs. It was stimulated by heat radiation and by the CO2 content, warmth, and humidity of an air stream. (3) Creeping direction: the larvae were attracted by heat in temperature gradients as weak as 0.04-degrees-C mm-1 and by dog hydrophilic skin surface extracts, but not by skin lipids or serum. (4) Penetration into agar was stimulated by heat, dog hydrophilic skin fraction, and dog serum. The effective component of serum had a molecular weight of between 5000 and 30,000 and proved to be a protein, since it lost its effectiveness after digestion with proteinases. Dog saliva, urine, milk, and various pure dog serum components did not stimulate penetration. A. caninum larvae were able to penetrate mouse skin repeatedly, but they did not follow the tracks of previously penetrated larvae in agar.