The impact of input fluctuations on the frequency-current relationships of layer 5 pyramidal neurons in the rat medial prefrontal cortex
The impact of input fluctuations on the frequency-current relationships of layer 5 pyramidal neurons in the rat medial prefrontal cortex
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DOI：
10.1523/jneurosci.4937-06.2007
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发表时间：
2007-03-21
影响因子：
5.3
通讯作者：
Giugliano, Michele
中科院分区：
文献类型：
--
作者：
Arsiero, Maura;Luescher, Hans-Rudolf;Giugliano, Michele
不规则皮层放电在神经元计算中的作用仍然存在争议，并且不清楚波动的突触电位携带的信号如何被下游神经元解码。我们研究了在体外的频率与电流（f-I）的关系，第5层（L5）锥体细胞的大鼠内侧前额叶皮层（mPFC）使用波动刺激。对躯体感觉皮层的研究表明，当输入平均值增加时，L5神经元对输入波动变得不敏感，并且它们的f-I响应变为线性。相比之下，我们的研究结果表明，mPFC L5锥体神经元保留了增加的敏感性输入波动，而他们的敏感性输入均值减少到接近零。这意味着L5 mPFC神经元的放电特性非常适合于编码输入波动，而不是输入平均值在其放电率，在网络水平上的信息处理和持续活动的稳定性的重要后果。
The role of irregular cortical firing in neuronal computation is still debated, and it is unclear how signals carried by fluctuating synaptic potentials are decoded by downstream neurons. We examined in vitro frequency versus current (f-I) relationships of layer 5 (L5) pyramidal cells of the rat medial prefrontal cortex (mPFC) using fluctuating stimuli. Studies in the somatosensory cortex show that L5 neurons become insensitive to input fluctuations as input mean increases and that their f-I response becomes linear. In contrast, our results show that mPFC L5 pyramidal neurons retain an increased sensitivity to input fluctuations, whereas their sensitivity to the input mean diminishes to near zero. This implies that the discharge properties of L5 mPFC neurons are well suited to encode input fluctuations rather than input mean in their firing rates, with important consequences for information processing and stability of persistent activity at the network level.