Protective effects of water‐soluble low‐molecular‐weight β‐(1,3‐1,6)D‐glucan purified from Aureobasidium pullulans GM‐NH‐1A1 against UFT toxicity in mice
Protective effects of water‐soluble low‐molecular‐weight β‐(1,3‐1,6)D‐glucan purified from Aureobasidium pullulans GM‐NH‐1A1 against UFT toxicity in mice
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从出芽短梗霉 GM-NH-1A1 中纯化的水溶性低分子量 β-(1,3-1,6)D-葡聚糖对小鼠 UFT 毒性的保护作用
DOI：
10.1211/jpp.61.06.0013
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发表时间：
2009
影响因子：
3.3
通讯作者：
Toshio Suzuki
中科院分区：
文献类型：
--
作者：
Y. Kimura;M. Sumiyoshi;Toshio Suzuki
目的5-氟尿嘧啶及其衍生物广泛应用于多种肿瘤的治疗。然而，它们的使用与胃肠道毒性、骨髓毒性和免疫毒性有关。在这项研究中，我们研究了从出芽短梗霉GM-NH-1A1中分离出的低分子β-葡聚糖对替加氟(替加氟(1-(2-四氢呋喃)-5-氟尿嘧啶)和尿嘧啶的联合作用)对小鼠结肠26肿瘤的保护作用。
Objectives 5‐Fluorouracil and its derivatives are widely used in the treatment of a variety of tumours. However, their use is associated with gastrointestinal toxicity, myelotoxicity and immune toxicity. In this study, we examined the protective effects of low‐molecular‐weight β‐glucan isolated from Aureobasidium pullulans GM‐NH‐1A1 against toxicity of UFT (combination of tegafur (1‐(2‐tetrahydrofuryl)‐5‐fluorouracil) and uracil) in mice bearing colon 26 tumours.