Proteases as modulators of tumor-stromal interaction: primary tumors to bone metastases.
Proteases as modulators of tumor-stromal interaction: primary tumors to bone metastases.
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DOI：
10.1016/j.bbcan.2007.11.001
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发表时间：
2008-04
期刊：
影响因子：
--
通讯作者：
T. Wilson;Rakesh K. Singh
中科院分区：
文献类型：
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作者：
T. Wilson;Rakesh K. Singh
当细胞经历致癌转化，当转化的细胞到达转移部位时，与周围基质发生复杂的相互作用。肿瘤和间质之间的这种对话最终决定了肿瘤细胞在给定的微环境中的成功。因此，了解其作用的分子机制对于开发新的治疗方法非常重要。蛋白水解酶是肿瘤与间质相互作用的主要参与者。这篇综述将集中于蛋白酶在调节乳腺癌和前列腺癌的肿瘤-间质相互作用中的作用，以及在有利于肿瘤生长的骨转移部位的作用。
As cells undergo oncogenic transformation and as transformed cells arrive at metastatic sites, a complex interplay occurs with the surrounding stroma. This dialogue between the tumor and stroma ultimately dictates the success of the tumor cells in the given microenvironment. As a result, understanding the molecular mechanisms at work is important for developing new therapeutic modalities. Proteases are major players in the interaction between tumor and stroma. This review will focus on the role of proteases in modulating tumor–stromal interactions of both primary breast and prostate tumors as well as at bone metastatic sites in a way that favors tumor growth.