Efficient and Selective Cleavage of the t‐Butoxycarbonyl Group from Di‐t‐butylimidodicarbonate Using Catalytic Bismuth(III) Bromide in Acetonitrile.
Efficient and Selective Cleavage of the t‐Butoxycarbonyl Group from Di‐t‐butylimidodicarbonate Using Catalytic Bismuth(III) Bromide in Acetonitrile.
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DOI：
10.1002/chin.200950051
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发表时间：
2009-09
期刊：
影响因子：
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通讯作者：
Jianlong Zheng;Biaolin Yin;Wenming Huang;Xiaopeng Li;Hequan Yao;Zhaogui Liu;Jiancun Zhang;
中科院分区：
文献类型：
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作者：
Jianlong Zheng;Biaolin Yin;Wenming Huang;Xiaopeng Li;Hequan Yao;Zhaogui Liu;Jiancun Zhang;
Di-t-butylimidodicarbonates can be chemoselectively and efficiently deprotected to the corresponding mono-BOC-protected amines in high yields using a catalytic amount of bismuth(III) bromide in acetonitrile at room temperature. This method is mild and compatible with the presence of a wide range of functional and other protecting groups in the substrates, such as TBDMS, MOM and mono-BOC or Cbz-protected amines, etc. The method has advantages of ease of operation and use of nontoxic and inexpensive catalyst.
