One motor driving two translocases.
One motor driving two translocases.
复制标题
一台电机驱动两个移位器。
DOI：
10.1038/nsmb1010-1166
复制
发表时间：
2010
影响因子：
16.8
通讯作者：
Patel,SmitaS
中科院分区：
文献类型：
--
作者：
Patel,SmitaS
在本期中，Wu et al.研究表明，参与修复双链DNA断裂的RecBC解旋酶使用一个ATPase马达驱动两个转位酶沿着相反的DNA链-很像全轮驱动引擎控制前轮和后轮的运动。这种机制可能会使RecBC更有效地装载到钝端DNA上，并通过缝隙和DNA损伤等障碍。
In this issue, Wuet al. show that the RecBC helicase, which is involved in repairing double-strand DNA breaks, uses one ATPase motor to drive two translocases along opposite strands of DNA—much as an all-wheel drive engine controls movement of both front and back wheels. This mechanism may allow RecBC to load onto blunt-end DNA more efficiently and to move through obstacles such as gaps and DNA damage.