Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study
Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study
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DOI：
10.1016/j.ajo.2015.04.021
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发表时间：
2015-07-01
影响因子：
4.2
通讯作者：
Yoshida, Akitoshi
中科院分区：
文献类型：
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作者：
Ishibazawa, Akihiro;Nagaoka, Taiji;Yoshida, Akitoshi
目得：评价光学相干断层扫描（OCT）血管造影术如何描述糖尿病视网膜病变（DR）患者的临床眼底表现。设计：前瞻性研究评价成像技术。方法：使用高速840 nm波长光谱域光学相干断层扫描仪（RTVue XR Avanti; Optovue，Inc，Fremont，加州，美国）扫描25例DR患者的47只眼。使用分裂频谱振幅去相关血管造影算法检测血流。荧光素血管造影（FA）的图像也获得了所有的眼睛和可视化微动脉瘤，视网膜非灌注区，和新生血管的能力进行了比较，与面OCT angiografts.Results：在42只眼睛，微动脉瘤检测FA黄斑附近出现局灶性扩张的囊状或梭形毛细血管的OCT血管造影的浅表和/或深毛细血管丛。FA显示的视网膜非灌注区在OCT血管造影片上表现为无毛细血管或毛细血管稀疏的病变。7只眼黄斑区视网膜无灌注区面积测量显示，浅丛和深丛的无灌注区范围存在差异。OCT血管造影4眼视盘新生血管结构清晰可见。在接受抗血管内皮生长因子治疗的眼睛中，对新血管中血流的减少和重新增加进行了量化。结论：OCT血管造影可以清晰地观察微动脉瘤和视网膜非灌注区域，并能够更仔细地观察视网膜毛细血管的每一层。还可以获得关于新船的定量信息。OCT血管造影术在临床上可用于评价Elsevier Inc. DR（C）2015治疗的微血管状态和治疗效果。All rights reserved.
PURPOSE: To evaluate how optical coherence tomography (OCT) angiography depicts clinical fundus findings in patients with diabetic retinopathy (DR).DESIGN: Prospective study evaluating imaging technology.METHODS: Forty-seven eyes of 25 patients with DR were scanned using a high-speed 840-nm-wavelength spectral-domain optical coherence tomography instrument (RTVue XR Avanti; Optovue, Inc, Fremont, California, USA). Blood flow was detected using the split-spectrum amplitude-decorrelation angiography algorithm. Fluorescein angiography (FA) images were also obtained in all eyes and the ability to visualize microaneurysms, retinal nonperfused areas, and neovascularization was compared with that of the en face OCT angiograms.RESULTS: In 42 eyes, microaneurysms detected by FA near the macula appeared as focally dilated saccular or fusiform capillaries on OCT angiograms of the superficial and/or deep capillary plexus. Retinal nonperfused area visualized by FA appeared as lesions with no or sparse capillaries on OCT angiograms. Area measurement of retinal nonperfusion near the macula in 7 eyes revealed a difference between the extent of nonperfused areas in superficial and deep plexuses. In 4 eyes, the vascular structures of neovascularization at the optic disc were clearly visualized on OCT angiograms. Decreases and re-increases of flow in new vessels were quantified in an eye treated with anti-vascular endothelial growth factor.CONCLUSIONS: OCT angiography can clearly visualize microaneurysms and retinal nonperfused areas and enables closer observation of each layer of the retinal capillaries. Quantitative information on new vessels can also be obtained. OCT angiography may be clinically useful to evaluate the microvascular status and therapeutic effect of treatments for DR. (C) 2015 by Elsevier Inc. All rights reserved.