Pericytes: A newly recognized player in wound healing.
Pericytes: A newly recognized player in wound healing.
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DOI：
10.1111/wrr.12415
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Wells A
中科院分区：
文献类型：
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作者：
Bodnar RJ;Satish L;Yates CC;Wells A
周细胞通常被认为具有稳定血管、确保血液屏障和调节毛细血管流量的作用。然而，新的报告表明，周细胞可能在关键时刻发挥作用，要么以最小的疤痕促进愈合，要么相反，促进纤维化和持续的疤痕形成。有利的是，周细胞可能驱动从愈合的再生阶段到消退阶段的过渡期间发生的大部分血管复旧。从病理学上讲，周细胞可以呈现纤维化表型并促进疤痕形成。这个观点将讨论周细胞参与伤口修复以及周细胞与皮肤实质细胞的关系。我们将进一步评估周细胞在与慢性伤口和纤维化相关的疾病进展中可能发挥的作用。
Pericytes have generally been considered in the context of stabilizing vessels, ensuring the blood barriers, and regulating the flow through capillaries. However, new reports suggest that pericytes may function at critical times to either drive healing with minimal scarring or, perversely, contribute to fibrosis and ongoing scar formation. Beneficially, pericytes likely drive much of the vascular involution that occurs during the transition from the regenerative to the resolution phases of healing. Pathologically, pericytes can assume a fibrotic phenotype and promote scarring. This perspective will discuss pericyte involvement in wound repair and the relationship pericytes form with the parenchymal cells of the skin. We will further evaluate the role pericytes may have in disease progression in relation to chronic wounds and fibrosis.