Speed and amplitude of lung tumor motion precisely detected in four-dimensional setup and in real-time tumor-tracking radiotherapy
Speed and amplitude of lung tumor motion precisely detected in four-dimensional setup and in real-time tumor-tracking radiotherapy
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DOI：
10.1016/j.ijrobp.2005.11.016
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发表时间：
2006-03-15
影响因子：
7
通讯作者：
Miyasaka, K
中科院分区：
文献类型：
--
作者：
Shirato, H;Suzuki, K;Miyasaka, K
背景：为了减少肺肿瘤注册的不确定性，我们开发了一种使用实时肿瘤跟踪放疗系统的四维（4D）设置系统。方法与材料：在治疗计划和治疗室日常设置期间，利用实时肿瘤跟踪放疗系统以每秒30次的速率记录1 ~ 2 min内基准标记物轨迹。为了最大限度地提高门控效率，使用4D设置系统调整患者在治疗床上的位置，该系统具有对治疗床的精细在线远程控制。结果：在4D设置系统中检测到的标记物轨迹清晰可见，可用于日常设置。检测到内部标记物的绝对振幅和速度的不同程度的分数间和分数内变化。在每次治疗期间，由于肿瘤位置的基线移动，需要进行重新调整。结论：4D定位系统可降低肿瘤运动的不确定性，提高门控照射的效率。考虑到本研究检测到的分段间和分段内的速度和幅度变化，采用实时跟踪技术进行4D放疗，阻断放疗是一种安全、经济的方法。(C) 2006爱思唯尔公司
Background: To reduce the uncertainty of registration for lung tumors, we have developed a four-dimensional (4D) setup system using a real-time tumor-tracking radiotherapy system.Methods and Materials: During treatment planning and daily setup in the treatment room, the trajectory of the internal fiducial marker was recorded for 1 to 2 min at the rate of 30 times per second by the real-time tumor-tracking radiotherapy system. To maximize gating efficiency, the patient's position on the treatment couch was adjusted using the 4D setup system with fine on-line remote control of the treatment couch.Results: The trajectory of the marker detected in the 4D setup system was well visualized and used for daily setup. Various degrees of interfractional and intrafractional changes in the absolute amplitude and speed of the internal marker were detected. Readjustments were necessary during each treatment session, prompted by baseline shifting of the tumor position.Conclusion: The 4D setup system was shown to be useful for reducing the uncertainty of tumor motion and for increasing the efficiency of gated irradiation. Considering the interfractional and intrafractional changes in speed and amplitude detected in this study, intercepting radiotherapy is the safe and cost-effective method for 4D radiotherapy using real-time tracking technology. (C) 2006 Elsevier Inc.