Insight into the patterns of cerebrospinal fluid flow in the human ventricular system using MR velocity mapping
Insight into the patterns of cerebrospinal fluid flow in the human ventricular system using MR velocity mapping
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DOI：
10.1016/j.neuroimage.2010.01.110
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发表时间：
2010-05-15
期刊：
影响因子：
5.7
通讯作者：
Ganslandt, Oliver
中科院分区：
文献类型：
--
作者：
Stadlbauer, Andreas;Salomonowitz, Erich;Ganslandt, Oliver
脑脊液(CSF)在人体脑室系统中的流动模式仍然没有完全了解其全部复杂性。知识基于对脑脊液流动曲线的解释或计算模拟。这两种方法都只提供了对脑脊液流动的空间和时间动态的不完整的洞察。时间分辨三维磁共振速度图以前曾被用来研究人类血管系统中正常和病理的血流模式。在这里，我们使用这项技术研究了40名正常志愿者脑室系统脑脊液流动的空间和时间动力学。根据心动周期内三维粒子轨迹线的计算，对脑脊液流动模式进行分类，发现侧脑室有一种均匀的流动模式，第三脑室有三种类型，第四脑室有两种类型。我们发现，无论是特定的脑脊液流动模式的存在，还是对脑脊液流动速度的影响，都没有显著的年龄效应。我们的结果首次详细展示了脑脊液在人体脑室系统中的流动模式。(C)2010 Elsevier Inc.保留所有权利。
The patterns of cerebrospinal fluid (CSF) flow within the human ventricular system are still not fully understood in all their complexity. Knowledge is based on either the interpretation of CSF flow curves or computational simulations. Both approaches only provide an incomplete insight into the spatial and temporal dynamics of CSF flow. Time-resolved three-dimensional magnetic resonance velocity mapping has previously been used to investigate normal and pathologic blood flow patterns in the human vascular system. Here we used this technique to study the spatial and temporal dynamics of CSF flow in the ventricular system of 40 normal volunteers. Classification of the patterns of CSF flow based on calculation of three-dimensional particle path lines over the cardiac cycle revealed one uniform flow pattern for the lateral ventricles, three categories for the third and two categories for the fourth ventricle. We found no significant aging effects on either the presence of a specific CSF flow pattern or on CSF flow velocities. Our results provide the first detailed demonstration of the patterns of CSF flow within the human ventricular system. (C) 2010 Elsevier Inc. All rights reserved.