Ceinical characteristics of the genetic variety of cutaneous melanoma in man
Ceinical characteristics of the genetic variety of cutaneous melanoma in man
复制标题
人类皮肤黑色素瘤遗传变异的临床特征
作者：
D. Anderson
在106例家族性和2,128例非家族性患者中比较了同时期黑色素瘤的特征。与非家族性患者相比，家族性患者表现出更年轻的年龄分布，首次诊断时的平均年龄显著更早，多发性原发性黑色素瘤的频率显著增加，生存率显著更高。家族性黑色素瘤的遗传机制显然是复杂的，可能涉及几个自主基因位点，除了受影响的或携带者女性传播的细胞质成分。这种细胞质成分的性质，是否来自细胞质细胞器或内含物，或其他机制仍有待确定。临床和遗传特征被解释为表明黑色素瘤的遗传多样性，但它是否是独特的或以前确定的黑色素瘤的临床和组织学类型的细分将需要进一步研究。认识和识别的遗传多样性和其临床特征具有重要的实际意义的早期检测和控制黑色素瘤。
The characteristics of coetaneous melanoma were compared in 106 familial and 2,128 non‐familial patients. Familial patients manifested a younger age distribution, a significantly earlier average age at first diagnosis, a significantly increased frequency of multiple primary melanomas, and a significantly higher survival rate than non‐familial patients. The genetic mechanism underlying the familial type of melanoma is apparently complex and may involve several autonomic gene loci, in addition to a cytoplasmic component transmitted by an affected or carrier female. The nature of this cytoplasmic component, whether deriving from a cytoplasmic organelle or inclusion, or some other mechanism is still to be determined. The clinical and genetic characteristics were interpreted as indicating a genetic variety of melanoma, but whether it is distinct or a subdivision of the clinical and histologic types of melanoma previously identified will require further study. Awareness and recognition of the genetic variety and its clinical characteristics have important practical relevance to the early detection and control of melanoma.