A molecular NAND gate based on Watson-Crick base pairing
A molecular NAND gate based on Watson-Crick base pairing
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DOI：
10.1021/ol005873c
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发表时间：
2000-06-15
期刊：
影响因子：
5.2
通讯作者：
Akkaya, EU
中科院分区：
文献类型：
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作者：
Baytekin, HT;Akkaya, EU
DNA结合染料4 '，6-diamidino-2-phenylindole（DAPI）通过荧光发射光谱中的位移发出AT碱基配对信号。信号传导遵循W-C碱基配对规则，并且最大的谱移需要dAMP和dTMP两者。因此，具有两个磷酸盐受体位点的染料充当接受核苷酸作为输入的分子NAND门。此外，当观察波长从470 nm改变到411.5 nm时，门在TRANSFER逻辑中起作用。
[GRAPHICS]A DNA-binding dye, 4',6-diamidino-2-phenylindole (DAPI) signals AT base pairing with a shift in the fluorescence emission spectrum. The signaling follows W-C base-pairing rules, and both dAMP and dTMP are required for the largest spectral shift. Thus, the dye with its two phosphate receptor sites functions as a molecular NAND gate accepting nucleotides as inputs. Moreover, when the observation wavelength is changed from 470 to 411.5 nm, the gate functions in TRANSFER logic.