Intense exercise increases circulating endocannabinoid and BDNF levels in humans-Possible implications for reward and depression
Intense exercise increases circulating endocannabinoid and BDNF levels in humans-Possible implications for reward and depression
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DOI：
10.1016/j.psyneuen.2011.09.017
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发表时间：
2012-06-01
影响因子：
3.7
通讯作者：
Meeusen, R.
中科院分区：
文献类型：
--
作者：
Heyman, E.;Gamelin, F. -X.;Meeusen, R.
已知内源性大麻素系统对抑郁症有积极影响，部分是通过其对神经营养因子的作用，如脑源性神经营养因子（BDNF）。由于BDNF也被认为是运动诱导的脑可塑性的主要候选分子，我们假设内源性大麻素系统是介导运动有益的抗抑郁作用的关键信号系统。在这里，我们调查了，在11名健康训练有素的男性骑自行车运动员，激烈的运动（60分钟，在55%，随后30分钟，在75% W-max）对内源性大麻素（花生四烯酸，AEA和2-花生四烯酸甘油，2-AG）的血浆水平的影响，以及它们与血清BDNF的可能联系。AEA水平在运动和恢复15 min时升高（P < 0.001），而2-AG水平保持稳定。BDNF水平在运动过程中显著升高，在恢复15 min后下降（P < 0.01）。运动结束时和恢复15 min后AEA与BDNF浓度呈正相关（r > 0.66，P < 0.05），提示运动时AEA升高可能是运动诱导外周BDNF水平升高的因素之一，恢复期AEA升高可能延缓BDNF恢复至基础水平。运动过程中AEA的产生可能是由皮质醇引发的，因为我们发现这两种化合物之间存在正相关性，并且已知皮质类固醇可以刺激内源性大麻素的生物合成。这些研究结果提供了人类的证据表明，急性运动是一种生理应激源，能够增加外周水平的AEA和BDNF可能是一种机制，AEA影响运动的神经可塑性和抗抑郁作用。(C)2011爱思唯尔有限公司版权所有。
The endocannabinoid system is known to have positive effects on depression partly through its actions on neurotrophins, such as Brain-Derived Neurotrophic Factor (BDNF). As BDNF is also considered the major candidate molecule for exercise-induced brain plasticity, we hypothesized that the endocannabinoid system represents a crucial signaling system mediating the beneficial antidepressant effects of exercise. Here we investigated, in 11 healthy trained male cyclists, the effects of an intense exercise (60 min at 55% followed by 30 min at 75% W-max) on plasma levels of endocannabinoids (anandamide, AEA and 2-arachidonoylglycerol, 2-AG) and their possible link with serum BDNF. AEA levels increased during exercise and the 15 min recovery (P < 0.001), whereas 2-AG concentrations remained stable. BDNF levels increased significantly during exercise and then decreased during the 15 min of recovery (P < 0.01). Noteworthy, AEA and BDNF concentrations were positively correlated at the end of exercise and after the 15 min recovery (r > 0.66, P < 0.05), suggesting that AEA increment during exercise might be one of the factors involved in exercise-induced increase in peripheral BDNF levels and that AEA high levels during recovery might delay the return of BDNF to basal levels. AEA production during exercise might be triggered by cortisol since we found positive correlations between these two compounds and because corticosteroids are known to stimulate endocannabinoid biosynthesis. These findings provide evidence in humans that acute exercise represents a physiological stressor able to increase peripheral levels of AEA and that BDNF might be a mechanism by which AEA influences the neuroplastic and antidepressant effects of exercise. (C) 2011 Elsevier Ltd. All rights reserved.