Pan-cancer analysis reveals the oncogenic role of 3-hydroxy-3-methylglutaryl-CoA synthase 1.
Pan-cancer analysis reveals the oncogenic role of 3-hydroxy-3-methylglutaryl-CoA synthase 1.
复制标题
泛癌分析揭示了 3-羟基-3-甲基戊二酰辅酶 A 合酶 1 的致癌作用。
DOI：
10.1002/cnr2.1562
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发表时间：
2022-09
期刊：
影响因子：
1.7
通讯作者：
Zhao, Liang
中科院分区：
文献类型：
--
作者：
Zhou, Cheng;Wang, Zhiqin;Cao, Yueqing;Zhao, Liang
新的研究表明，3-羟基-3-甲基戊二酰辅酶A合酶1（HMGCS 1）在广泛的人类癌症中起着重要的致癌作用，但没有泛癌症证据表明HMGCS 1与各种肿瘤类型之间的关系。基于大量临床数据，探索HMGCS 1在各种肿瘤类型中的潜在作用。我们基于现有最全面的数据库，包括TCGA、GSCA、临床蛋白质组肿瘤分析联盟、Kaplan-Meier Plotter数据集、GEPIA 2、TIMER 2、STRING和GDSC数据集，对30多种肿瘤类型进行了泛癌症分析。HMGCS 1在大多数肿瘤中呈高表达，与预后呈负相关。癌相关成纤维细胞和CD 8 + T细胞的浸润水平与HMGCS 1表达密切相关。HMGCS 1基因在不同癌症中最常见的遗传变异是扩增，而突变频率较低。ACAT 2与MVD密切相关，并与HMGCS 1结合。途径富集分析表明，HMGCS 1积极参与类固醇的生物合成。此外，高HMGCS 1表达可降低GDSC数据集中对大多数药物的敏感性。我们的研究揭示了HMGCS 1在癌症中的潜在致癌作用。
Emerging studies reveals that 3‐hydroxy‐3‐methylglutaryl‐CoA synthase 1 (HMGCS1) plays vital oncogenic roles in a broad spectrum of human cancers, but there is no pan‐cancer evidence on the relationship between HMGCS1 and various tumor types. To explore the potential role of HMGCS1 across various tumor types based on big clinical data. We conducted a pan‐cancer analysis across more than 30 tumor types, based on the most comprehensive database available, including TCGA, GSCA, clinical proteomic tumor analysis consortium, Kaplan–Meier Plotter dataset, GEPIA2, TIMER2, STRING, and GDSC dataset. HMGCS1 was highly expressed and negatively correlated with the prognosis in most cancer types. The infiltration levels of cancer associated fibroblast and CD8+ T‐cell were closely associated with HMGCS1 expression. Amplification was the most common genetic alteration of HMGCS1 in different cancers, while the frequency of mutation was low. Besides, ACAT2 and MVD were closely correlated and bind to HMGCS1. Pathway enrichment analysis indicated that HMGCS1 was actively involved in steroid biosynthesis. Moreover, high HMGCS1 expression could reduce the sensitivity to most drugs in the GDSC dataset. Our study revealed the potential oncogenic role of HMGCS1 in cancers.