Challenges of Randomized Controlled Surgical Trials
Challenges of Randomized Controlled Surgical Trials
复制标题
DOI：
10.1016/j.ocl.2009.11.001
复制
发表时间：
2010-04-01
影响因子：
1.8
通讯作者：
James, Michelle A.
中科院分区：
文献类型：
--
作者：
Campbell, Angela J.;Bagley, Anita;James, Michelle A.
循证医学的概念在医学界获得了广泛的支持，因为基于严格科学研究信息的临床决策最有可能提供最佳护理。研究人员试图通过观察性研究或随机对照试验（RCT）来回答临床问题。观察性研究目前在外科文献中占主导地位，但提供的证据水平低于随机对照试验。RCT在伦理上以临床平衡为基础，通过设盲可以进一步降低偏倚或其他混杂因素的可能性。本文讨论了实施外科RCT的障碍。
The concept of evidence-based medicine has gained broad support in the medical community, because clinical decisions based on information from rigorous scientific study are most likely to provide optimal care. Researchers attempt to answer clinical questions using either observational studies or randomized controlled trials (RCTs). Observational studies currently dominate the surgical literature but provide a level of evidence inferior to RCTs. RCTs are ethically grounded in clinical equipoise and may further reduce the potential for bias or other confounding factors by blinding. This article discusses the barriers to implementation of surgical RCTs.