Multiple resistance to macrocyclic lactones in the sheep scab mite Psoroptes ovis
Multiple resistance to macrocyclic lactones in the sheep scab mite Psoroptes ovis
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DOI：
10.1016/j.vetpar.2019.07.007
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发表时间：
2019-08-01
影响因子：
2.6
通讯作者：
Wall, R.
中科院分区：
文献类型：
--
作者：
Sturgess-Osborne, C.;Burgess, S.;Wall, R.
羊疥疮是羊的一种传染性极强的致残性疾病。这种体外寄生虫感染对英国羊养殖业有很高的经济和动物福利影响。最近的研究表明，Psoroptes螨对莫西菌素（一种广泛使用的大环内酯（ML）治疗疥疮的药物）具有耐药性，目前的研究比较了三种常用的大环内酯治疗方法（莫西菌素、伊维菌素和多拉菌素）对来自对治疗无反应的暴发人群的绵羊假单胞菌的毒性。这些暴发人群来自威尔士和英格兰西南部。所提出的数据表明，有抗性的所有三种可用的ML化合物在种群中的Psoroptes螨。然而，反应的相当大的差异表明，在所有提交的病例中，报告缺乏疗效并不仅仅是耐药性的原因；其他患者缺乏反应可能与不适当的治疗应用或管理有关。这些数据强调了适当使用这些化合物的重要性，以便将国家疥疮发病率控制在符合可接受的动物福利标准的水平，同时努力减少耐药性的发展和传播。
The astigmatid mite Psoroptes ovis (Acari: Proroptidae) causes the highly contagious and debilitating ovine disease, sheep scab. This ectoparasitic infection has a high economic and animal welfare impact on British sheep farming. Following recent work demonstrating resistance of Psoroptes mites to moxidectin, a widely used macrocyclic lactone (ML) treatment for scab, the current study compared the toxicity of three of the commonly administered macrocylic lactone therapeutic treatments (moxidectin, ivermectin and doramectin) to P. ovis from outbreak populations that had appeared unresponsive to treatment. These outbreak populations were from Wales and south west England. The data presented demonstrate that there is resistance to all three available ML compounds in populations of Psoroptes mites. However, considerable variation in response suggested that resistance alone was not responsible for the reported lack of efficacy in all of the submitted cases; lack of response in others may be associated with inappropriate treatment application or management. These data highlight the importance of the appropriate use of these compounds to manage national scab incidence at levels that are consistent with acceptable animal welfare standards, while attempting to reduce the development and spread of resistance.