The effects of Mitochondria-associated long noncoding RNAs in cancer mitochondria: new players in an old arena
The effects of Mitochondria-associated long noncoding RNAs in cancer mitochondria: new players in an old arena
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DOI：
10.1016/j.critrevonc.2018.08.005
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Jiuwei Cui
中科院分区：
文献类型：
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作者：
Yijing Zhao;Lemeng Sun;Rachel R.Wang;Ji-Fan Hu;Jiuwei Cui
LncRNAs, as new players in the old battle against cancer, are significant components of gene regulatory networks..Mitochondria-associated lncRNAs have newly been discovered to work in concert with transcription.factors and epigenetic regulators to modulate mitochondrial gene expression and mitochondrial function. Many.mitochondria-associated lncRNAs regulate mitochondrial biosynthesis, bioenergetics, apoptosis and possibly.govern the cross-talk of mitochondria with nuclei. The complexity of mitochondria-associated lncRNAs is now.just starting to envisage. In this review, we collected available evidence that reinforces the importance of mitochondria-.associated lncRNA in cancer metabolism, apoptosis, and cell senescence. For the non-exhaustive list.of mitochondria-associated lncRNAs, we identified 18 lncRNAs in total (mitochondria-encoded lncRNAs or.nuclei encoded mitochondria function associated lncRNAs) as emerging new players in cancer mitochondrial.function. As lncRNAs exhibit cancer-type-specific expression patterns, they are attractive targets for selective.therapeutic interventions. Manipulation of their function may thus represent a valuable strategy for future.cancer treatment.
