Less sensitivity for late airway inflammation in males than females in BALB/c mice
Less sensitivity for late airway inflammation in males than females in BALB/c mice
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DOI：
10.1046/j.1365-3083.2003.01269.x
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发表时间：
2003-06-01
影响因子：
3.7
通讯作者：
Morimoto, M
中科院分区：
文献类型：
--
作者：
Hayashi, T;Adachi, Y;Morimoto, M
一些研究已经使用哮喘小鼠模型研究了过敏性气道炎症，一种辅助性T细胞2（Th 2）型免疫应答。然而，目前还没有报道描述晚期气道炎症（LAI）敏感性的性别差异。在雄性和雌性或假手术雄性和去势雄性中比较了卵白蛋白在成年BALB/c小鼠中诱导的LAI。与雌性动物相比，雄性动物的支气管-细支气管炎症不太严重，伴嗜酸性粒细胞和淋巴细胞浸润，支气管肺泡液中此类细胞的含量较低。此外，脾细胞中的白细胞介素-4（IL-4）mRNA表达水平在雄性中低于雌性。阉割的雄性表现得和雌性一样。此外，与假手术的雄性相比，去势的雄性血液中的睾酮水平较低。目前的结果表明，在男性LAI的敏感性较低，可能是因为减少了Th 2细胞反应相比，女性。此外，睾酮，至少部分，可能是负责减少Th 2细胞反应在男性体内。
Several studies have investigated allergic airway inflammation, a T helper 2 (Th2)-type immune response, using a mouse model of asthma. At present, however, no reports have described sex differences in the sensitivity of late airway inflammation (LAI). The LAI induced by ovalbumin in adult BALB/c mice was compared in males and females or sham-operated males and castrated males. The males showed less severe bronchial-bronchiolar inflammation with infiltration of eosinophils and lymphocytes and lower content of such cells in bronchoalveolar fluid than the females. Moreover, interleukin-4 (IL-4) mRNA expression levels in splenic cells were lower in the males than in the females. Castrated males performed like the females. Moreover, when compared with the sham-operated males, the castrated males showed lower testosterone levels in the blood. The present results suggest that less sensitivity for LAI in the males may be because of the decreased Th2 cell responses compared with the females. Moreover the testosterone, at least in part, may be responsible for the decreased Th2 cell responses in males in vivo .