A pilot randomized trial of a cognitive reappraisal obesity prevention program
A pilot randomized trial of a cognitive reappraisal obesity prevention program
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DOI：
10.1016/j.physbeh.2014.10.022
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发表时间：
2015-01-01
影响因子：
2.9
通讯作者：
Gau, Jeff M.
中科院分区：
文献类型：
--
作者：
Stice, Eric;Yokum, Sonja;Gau, Jeff M.
背景/目标：评估一个选择性肥胖预防计划，促进使用认知再评价来减少奖赏区反应和增加抑制区对高脂肪/高糖食物的反应，并减少脂肪和糖的摄入，以防止迟钝的奖赏区对摄入这些食物的反应。由于体重问题而有未来体重增加风险的年轻人（N = 148）被随机分配到这个新的预防计划中（注意健康），一种替代预防计划，促进参与者驱动的热量摄入的逐渐减少和体力活动的增加（健康体重），或肥胖教育视频控制条件，在术前，术后和6个月随访时完成评估。一个子集的健康和控制参与者完成了功能磁共振成像扫描在前和后评估的神经反应的图像的高脂肪/糖的食物和接收和预期收到的高脂肪/糖food.Results：健康的参与者表现出显着更大的减少体脂比控制和热量摄入的脂肪和糖比健康体重的参与者。Minding Health参与者还表现出抑制性控制区域的更大激活和注意力/期望区域的激活减少，以响应相对于预测试和控制的美味食物图像。然而，健康体重的参与者表现出更大的减少体重指数和饮食失调症状比Minding Health participants.Conclusions：虽然Minding Health干预产生了一些假设的影响，它没有产生持久的减少体脂或体重指数，并显示有限的影响，对神经反应，这意味着它将是至关重要的，以增加这种新的预防方案的疗效。(C)2014 Elsevier Inc. All rights reserved.
Background/Objectives: Evaluate a selective obesity prevention program promoting use of cognitive reappraisals to reduce reward region response and increase inhibitory region response to high-fat/high-sugar foods and reduce intake of fat and sugar to prevent blunted reward region response to intake of such foods.Subjects/Methods: Young adults at risk for future weight gain by virtue of weight concerns (N = 148) were randomized to this new prevention program (Minding Health), an alternative prevention program promoting participant-driven gradual reductions in caloric intake and increases in physical activity (Healthy Weight), or an obesity education video control condition, completing assessments at pre-, post-, and 6-month follow-up. A subset of Minding Health and control participants completed an fMRI scan at pre- and post-assessing neural response to images of high-fat/sugar foods and to receipt and anticipated receipt of a high-fat/sugar food.Results: Minding Health participants showed significantly greater reductions in body fat than controls and caloric intake from fat and sugar than Healthy Weight participants. Minding Health participants also showed greater activation of an inhibitory control region and reduced activation of an attention/expectation region in response to palatable food images relative to pretest and controls. However, Healthy Weight participants showed greater reductions in BMI and eating disorder symptoms than Minding Health participants.Conclusions: Although the Minding Health intervention produced some of the hypothesized effects, it did not produce lasting reductions in body fat or BMI and showed limited effects on neural responsivity, implying it will be vital to increase the efficacy of this new prevention program. (C) 2014 Elsevier Inc. All rights reserved.