CSF biomarker levels in early and late onset Alzheimer's disease
CSF biomarker levels in early and late onset Alzheimer's disease
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DOI：
10.1016/j.neurobiolaging.2008.02.007
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发表时间：
2009-12-01
影响因子：
4.2
通讯作者：
van der Flier, Wiesje M.
中科院分区：
文献类型：
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作者：
Bouwman, Femke H.;Schoonenboom, Niki S. M.;van der Flier, Wiesje M.
目的比较AD患者和对照组脑脊液中Aβ(1-42)、总tau(Tau)和181位苏氨酸磷酸化tau(ptau-181)的水平。248例AD患者(48%男性)和127例对照组(男性51%，志愿者22例，主诉患者105例)进行了腰椎穿刺术。患者和对照组均被分为青年组(=65岁)。三种生物标志物均显示出诊断的主要效应(p
Objective To compare CSF levels of beta-amyloid 1-42 (A beta(1-42)), total tau (tau) and tau phosphorylated at threonine 181 (ptau-181) between AD patients and controls according to ageMethods. 248 AD patients (48% men) and 127 controls (51% men, 22 volunteers and 105 subjective complainers) underwent lumbar puncture. Both patients and controls were divided into a young (= 65 years) groupResults. All three biomarkers showed main effects of diagnosis (p