Relapse of new world diffuse cutaneous leishmaniasis caused by Leishmania (Leishmania) mexicana after miltefosine treatment
Relapse of new world diffuse cutaneous leishmaniasis caused by Leishmania (Leishmania) mexicana after miltefosine treatment
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DOI：
10.4269/ajtmh.2006.75.1074
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发表时间：
2006-12-01
影响因子：
3.3
通讯作者：
Hashiguchi, Yoshihisa
中科院分区：
文献类型：
--
作者：
Calvopina, Manuel;Gomez, Eduardo A.;Hashiguchi, Yoshihisa
一名35岁的男子与19年的历史，缓慢发展的弥漫性皮肤利什曼病的治疗与口服米替福新，50毫克，每天三次。该患者在米替福新治疗4个月后有反应，所有结节性病变和斑块从整个体表清除，并有阴性的皮肤涂片和利什曼原虫培养。然而，在停用米替福新两个月后，皮肤病变再次出现，并在样本中观察到寄生虫。复发病灶对额外的两个月米替福新疗程没有反应。未观察到米替福新的实验室或临床不良事件。从皮损处分离寄生虫，经同工酶电泳鉴定为墨西哥利什曼原虫。
A 35-year-old man with a 19-year history of slowly evolving diffuse cutaneous leishmaniasis was treated with oral miltefosine, 50 mg three times a day. The patient responded after four months of miltefosine treatment with clearance of all nodular lesions and plaques from the entire body surface and had negative slit-skin smears and cultures for Leishmania. However, two months after stopping miltefosine, skin lesions reappeared and parasites were observed in samples. The relapsed lesions did not respond to an additional two-month course of miltefosine. No laboratory or clinical adverse events to miltefosine were observed. Parasites from skin lesions were cultured and identified as Leishmania (Leishmania) mexicana by isoenzyme electrophoresis.