Adherens junctions in endothelial cells regulate vessel maintenance and angiogenesis
Adherens junctions in endothelial cells regulate vessel maintenance and angiogenesis
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DOI：
10.1016/s0049-3848(07)70124-x
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发表时间：
2007-01-01
影响因子：
7.5
通讯作者：
Dejanaa, Etisabetta
中科院分区：
文献类型：
--
作者：
Lampugnani, Maria Grazia;Dejanaa, Etisabetta
细胞与细胞的连接指导静止血管和血管生成血管中的内皮反应。内皮细胞表达紧密连接和粘附连接。尽管它们的具体分子组成不同，但这些连接复合物呈现出相对相似的结构和功能排列。结合相邻细胞上同质相同分子的跨膜粘附蛋白代表了两种类型连接的核心成分。这种细胞间识别启动了一系列信号事件。信号传输是通过与细胞质和跨膜伙伴的相互作用介导的。粘附连接沿着维管树无处不在。在这些结构中，VE-钙粘蛋白及其细胞内伙伴介导粘附。体外和体内数据表明，VE-钙粘蛋白是静止血管内皮完整性和新血管正确组织所必需的。 VE-钙粘蛋白通过不同的机制调节内皮功能，其中包括：（i）直接激活信号分子，如 PI3 激酶和 Rac，以维持肌动蛋白细胞骨架的存活和组织； (ii) 基因转录的调节，可能调节转录辅助因子（如 β-连环蛋白和 p120）的核水平； (iii) 与生长因子受体（例如 VEGF 2 型受体 (VEGFR-2)）形成复合物并调节其信号传导特性。 (c) 2007 Elsevier B.V. 保留所有权利。
Cell to cell junctions direct endothelial responses both in quiescent and angiogenic vessels. Endothelial cells express both tight and adherens junctions. Although different in their specific molecular composition, these junctional complexes present a relatively similar structural and functional arrangement. Transmembrane adhesive proteins that bind homophilically identical molecules on adjacent cells represent the core component in both types of junctions. This intercellular recognition starts a sequence of signaling events. Signal transmission is mediated through the interaction with cytoplasmic and transmembrane partners. Adherens junctions are ubiquitous along the vascular tree. In these structures VE-cadherin and its intracellular partners mediate adhesion. In vitro and in vivo data show that VE-cadherin is required for endothelial integrity in quiescent vessels and for the correct organization of new vessels. VE-cadherin regulates endothelial functions through different mechanisms which include: (i) direct activation of signaling molecules such as PI3kinase and Rac, to sustain survival and organization of the actin cytoskeleton; (ii) regulation of gene transcription, possibly modulating the nuclear level of transcription co-factors such as beta-catenin and p120; (iii) formation of complexes with growth factor receptors, such as the type 2 receptor of VEGF (VEGFR-2) and modulation of their signaling properties. (c) 2007 Elsevier B.V. All rights reserved.