Proinflammatory Cytokine Secretion in a Patient With Recurrent Neuroblastoma Related to the Onset of Malignancy-associated Hemophagocytic Lymphohistiocytosis.
Proinflammatory Cytokine Secretion in a Patient With Recurrent Neuroblastoma Related to the Onset of Malignancy-associated Hemophagocytic Lymphohistiocytosis.
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复发性神经母细胞瘤患者的促炎细胞因子分泌与恶性肿瘤相关的噬血细胞淋巴组织细胞增多症的发生有关。
DOI：
10.1097/mph.0000000000001617
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Fukao T.
中科院分区：
文献类型：
--
作者：
10.Nozawa A.;Ozeki M.;Yasue S.;Endo S.;Ohe N.;Miyazaki T.;Fukao T.
恶性相关噬血细胞性淋巴组织细胞增生症（M-HLH）的发病可能与恶性细胞分泌促炎细胞因子有关。我们在此报告一位复发性神经母细胞瘤患者，因脑转移手术后发展为噬血细胞性淋巴组织细胞增生症，并于化疗后复发。复发肿瘤中的神经母细胞瘤细胞肿瘤坏死因子-α和白细胞介素-6阳性，而原发部位为阴性。神经母细胞瘤细胞分泌的促炎细胞因子可能与我们患者的M-HLH发病机制有关。在治疗晚期神经母细胞瘤时应注意M-HLH的可能发展。
The onset of malignancy-associated hemophagocytic lymphohistiocytosis (M-HLH) may be associated with the secretion of proinflammatory cytokines from malignant cells. We here report a patient with recurrent neuroblastoma who developed hemophagocytic lymphohistiocytosis after surgery for brain metastases and relapsed after chemotherapy. The neuroblastoma cells in the recurrent tumor were positive for tumor necrosis factor-α and interleukin-6, whereas the primary site was negative. The secretion of proinflammatory cytokines from neuroblastoma cells may have been related to the pathogenesis of M-HLH in our patients. We should pay attention to possible development of M-HLH when treating advanced neuroblastoma.