Questionnaire based assessment of risk factors for primary biliary cirrhosis.
Questionnaire based assessment of risk factors for primary biliary cirrhosis.
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DOI：
10.1016/j.dld.2013.01.028
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发表时间：
2013-07
影响因子：
4.5
通讯作者：
Lazaridis, Konstantinos N.
中科院分区：
文献类型：
--
作者：
Lammert, Craig;Nguyen, Douglas L.;Juran, Brian D.;Schlicht, Erik;Larson, Joseph J.;Atkinson, Elizabeth J.;Lazaridis, Konstantinos N.
原发性胆汁性肝硬化是一种以免疫介导的胆管破坏为特征的胆汁淤积性肝病。其发病机制在很大程度上是未知的，虽然环境和遗传易感性之间的复杂的相互作用被提出。使用详细的患者问卷确定疾病风险因素，并将研究结果与3份已发表的报告进行比较。从马约诊所原发性胆汁性肝硬化遗传流行病学登记处的522例病例和616例对照中前瞻性收集问卷资料。病例组和对照组的反应进行了比较，采用逻辑回归，调整招募年龄，性别和教育水平。有规律吸烟者明显多于对照组（P < 0.001）。两组患者的尿路感染史相似，但报告多个尿路感染的病例比对照组多（P < 0.001）。其他自身免疫性疾病的发生率在病例组高于对照组（P < 0.001）。一级亲属原发性胆汁性肝硬化患病率病例组高于对照组（P < 0.001）。我们的研究证实了先前报道的与疾病风险相关的风险因素。鉴于基因和环境相互作用的潜在重要性，进一步研究环境危险因素，考虑遗传背景可能会提供新的见解原发性胆汁性肝硬化的发病机制。
Primary Biliary Cirrhosis is a cholestatic liver disease characterized by immune-mediated destruction of bile ducts. Its pathogenesis is largely unknown, although complex interactions between environment and genetic predisposition are proposed. Identify disease risk factors using a detailed patient questionnaire and compare study findings to 3 published reports. Questionnaire data were prospectively collected from 522 cases and 616 controls of the Mayo Clinic Primary Biliary Cirrhosis Genetic Epidemiology Registry. Case and control responses were compared using logistic regression, adjusting for recruitment age, sex, and education level. Cases reported ever regularly smoking cigarettes more frequently than controls (P < 0.001). History of urinary tract infection (UTI) was similar between groups; however, cases reported multiple UTIs more commonly than controls (P < 0.001). Frequency of other autoimmune disease was higher in cases than controls (P < 0.001). As well, prevalence of primary biliary cirrhosis among first-degree relatives was higher in case families than control families (P < 0.001). Our study confirms prior reported risk factors associated with disease risk. Given the potential importance of gene and environment interactions, further examination of environmental risk factors considering genetic background may provide new insight into primary biliary cirrhosis pathogenesis.
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影响因子：
25.7
作者：
Jones, DEJ;Watt, FE;James, OFW
通讯作者：
James, OFW
影响因子：
13.5
作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.1433063100
发表时间：
2003-07-08
影响因子：
11.1
作者：
Xu, LZ;Shen, ZW;Mason, A
通讯作者：
Mason, A