A comparison of equivalent clinical potencies of neuroleptics as used to treat schizophrenia and affective disorders.
A comparison of equivalent clinical potencies of neuroleptics as used to treat schizophrenia and affective disorders.
复制标题
用于治疗精神分裂症和情感障碍的精神安定药的等效临床效力的比较。
DOI：
10.1016/0022-3956(77)90011-5
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发表时间：
1977
影响因子：
4.8
通讯作者：
J. S. Torgow
中科院分区：
文献类型：
--
作者：
R. Wyatt;J. S. Torgow
为了初步检查抗精神病药在诊断方面的特异性，我们进行了文献综述。将抗精神病药在治疗精神分裂症中的用途与在治疗情感障碍中的用途进行了比较。计算并比较了被发现同样有效的药物的等效临床效力（诊断内比较）。人们发现这种跨疾病的相关性很高，这归因于药物可能通过一个或两个核心异常的外围系统来影响治疗。大脑多巴胺系统被认为是受影响的区域。
In a preliminary attempt to examine the neuroleptics' specificity with respect to diagnosis, a literature review was conducted. The neuroleptics' use in treating schizophrenia was compared with their use in treating the affective disorders. Equivalent clinical potencies of drugs found to be equally efficacious (intra-diagnosis comparisons) were computed and compared. This correlation across disorders was found to be high and was attributed to the possibility that the drugs effect their treatment through a system peripheral to one or both core abnormalities. The brain dopamine systems were proposed as the affected area.