Impaired recency judgments and intact novelty judgments after fornix transection in monkeys
Impaired recency judgments and intact novelty judgments after fornix transection in monkeys
复制标题
DOI：
10.1523/jneurosci.3796-03.2004
复制
发表时间：
2004-02-25
影响因子：
5.3
通讯作者：
Buckley, MJ
中科院分区：
文献类型：
--
作者：
Charles, DP;Gaffan, D;Buckley, MJ
在4个基于延迟样本匹配任务的实验中，对正常对照猴和断孔猴分别给予5个样本刺激序列，然后分别在实验1、实验2、实验3和实验4中进行会话内近代性（WSR）和会话间近代性（BSR）混合测试。在WSR测试中，猴子选择两个样本中最近发生的一个。在BSR和AN测试中，猴子被要求从之前的序列中选择一个样本，而不是当前会话中未见过的箔片（BSR）或以前从未出现过的AN箔片。当WSR和BSR测试混合时（实验1），穹窿猴在两种测试中的表现都低于对照猴，尽管这种差异没有统计学意义。在实验2中，穹窿猴在单独的BSR测试中明显受损，在该测试中，对前面出现的刺激序列的记忆可以与之前出现的刺激序列的记忆相竞争。在AN测试（实验3）中，穹窿猴在区分以前经历过的刺激和以前未见过的刺激方面的表现与对照动物相同。在实验4中，穹窿横断对单独使用WSR的实验结果有显著影响。综上所述，这些结果表明穹窿的一个特殊作用是处理时间信息。
Over four experiments based on the delayed matching-to-sample task, fornix-transected and normal control monkeys were presented with a sequence of five sample stimuli and then received intermixed within-session recency (WSR) and between-session recency (BSR) tests in experiment 1, only BSR tests in experiment 2, only absolute novelty (AN) tests in experiment 3, or only WSR tests in experiment 4. In WSR tests, monkeys chose which of two samples had occurred more recently in the immediately preceding sequence. In BSR and AN tests, monkeys were required to choose one sample from the immediately preceding sequence in preference to a foil unseen in the present session (BSR) or an AN foil that had never been presented before. When tests of WSR and BSR were intermixed (experiment 1), fornix monkeys performed below the level of the control monkeys in both types of test, although this difference was not statistically significant. In experiment 2, fornix monkeys were significantly impaired on tests of BSR alone, in which memory for a stimulus presented in an immediately preceding sequence could compete with memory for a foil presented in an earlier training session. In tests of AN (experiment 3), fornix monkeys performed at the same level as control animals in distinguishing a previously experienced stimulus from a previously unseen foil. In experiment 4, fornix transection significantly impaired tests of WSR alone. Taken together, these results suggest that one specialized role of the fornix is to process temporal information.