Usefulness of serial determinations of myoglobin and creatine kinase in serum compared for assessment of acute myocardial infarction.
Usefulness of serial determinations of myoglobin and creatine kinase in serum compared for assessment of acute myocardial infarction.
复制标题
血清中肌红蛋白和肌酸激酶连续测定对评估急性心肌梗死的有用性进行比较。
DOI：
10.1093/clinchem/29.3.469
复制
发表时间：
1983
影响因子：
9.3
通讯作者：
W. Walker
中科院分区：
文献类型：
--
作者：
J. Cairns;E. Missirlis;W. Walker
21例首次心肌梗死患者在疼痛发作后48-72小时内每2小时连续采血测定血清肌酸激酶（CK）和肌红蛋白。第一次血液样本，在平均时间为4.4小时后梗死发作，总是显示增加肌红蛋白（平均值，8.3倍正常），而CK通常是正常的（平均值，1.6倍正常）。肌红蛋白峰值出现早于CK峰值（9.9 h vs 21.6 h，p <0.0005），但峰值之间存在显著相关性（肌红蛋白= 0.384 CK- 0.264，r = 0.794，p <0.0005）。CK和肌红蛋白的平均指数消失率（Kd）分别为0.00106 min-1和0.00265 min-1（p <0.0005）。肌红蛋白的消失是很好地描述了一个单指数的表达，除了在两名患者。肌红蛋白增加的总持续时间显著短于CK（34.7 h vs 74.4 h，p <0.0005）。
Twenty-one patients with their first myocardial infarction underwent serial blood sampling every 2 h for determination of serum creatine kinase (CK) and myoglobin during the first 48-72 h after onset of pain. The first blood sample, obtained at a mean time of 4.4 h after infarct onset, invariably showed increased myoglobin (mean, 8.3-fold normal), whereas CK was often normal (mean, 1.6-fold normal). Peak myoglobin values occurred earlier than peak CK values (9.9 h vs 21.6 h, p less than 0.0005), but there was a significant correlation of peak values (myoglobin = 0.384CK - 0.264, r = 0.794, p less than 0.0005). The mean exponential disappearance rate (Kd) of CK was 0.00106 min-1 and of myoglobin was 0.00265 min-1 (p less than 0.0005). The disappearance of myoglobin was well described by a mono-exponential expression except in two patients. The total duration of the increase in myoglobin was significantly less than that of CK (34.7 h vs 74.4 h, p less than 0.0005).