The effect of exercise on secretory and natural immunity.
The effect of exercise on secretory and natural immunity.
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运动对分泌和自然免疫力的影响。
DOI：
10.1007/978-1-4684-5344-7_102
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发表时间：
1987
影响因子：
--
通讯作者：
Tomasi,TB
中科院分区：
文献类型：
--
作者：
Mackinnon,LT;Chick,TW;vanAs,A;Tomasi,TB
竞技运动员“过度训练”后反复出现呼吸道感染的频率很高，促使这项研究探讨长时间剧烈运动对粘膜免疫球蛋白 (Ig) 的影响。该实验室之前的一项研究表明，精英运动员（美国国家北欧滑雪队）的静息唾液 IgA 水平低于年龄匹配的对照受试者，并且在两到三个小时的力竭运动后（1981 年美国国家北欧滑雪比赛），IgA 水平进一步下降 (1)。目前还不清楚 IgA 的减少是由于运动的影响、寒冷 (1°C) 的影响、竞争压力还是多种因素的影响。为了进一步阐明锻炼的作用，我们在受控环境和非竞争性实验室环境中研究了竞技自行车手。我们在运动后两天跟踪分泌型 Ig 水平，以研究运动停止后抑制的时间过程以及恢复到基线水平的时间过程。此外，我们还测量了运动前后的 NK 细胞毒活性，以研究剧烈运动是否会改变其他免疫参数。
The high frequency of recurrent respiratory infections following “overtraining” in competitive athletes prompted this study to examine the effects of intense prolonged exercise on mucosal immunoglobulins (Ig). In a previous study from this laboratory, it was shown that in elite athletes (US National Nordic ski team) resting salivary IgA levels are lower than in age-matched control subjects, and that IgA levels decrease further after two to three hours of exhaustive exercise (1981 US National Nordic ski competition) (1). It was unclear whether the decreases in IgA were due to the effects of exercise, to the effects of cold (1°C), to the stress of competition, or to a combination of factors. To further elucidate the role of exercise, we studied competitive bicyclists in a controlled environment and noncompetitive laboratory setting. We followed secretory Ig levels for two days after exercise in order to study the time course of suppression and return to baseline levels following cessation of exercise. In addition, we measured NK cytotoxic activity before and after exercise in order to study whether severe exercise alters other immune parameters.