ADAMTS9, a novel member of the ADAM-TS/metallospondin gene family
ADAMTS9, a novel member of the ADAM-TS/metallospondin gene family
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DOI：
10.1006/geno.2000.6246
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发表时间：
2000-08-01
期刊：
影响因子：
4.4
通讯作者：
Maki, RA
中科院分区：
文献类型：
--
作者：
Clark, ME;Kelner, GS;Maki, RA
ADAM-TS/metallopondin基因编码与ADAM金属蛋白酶-去整合素家族具有结构同源性的蛋白质新家族。然而，与其他亚当斯不同，这些蛋白质在羧基末端含有血小板反应蛋白1型（TSP 1）重复序列，并且是分泌蛋白而不是膜结合蛋白。ADAM-TS家族成员参与蛋白多糖的切割、器官发育过程中的形状控制和血管生成的抑制。我们克隆了一个新的ADAM-TS/metallopondin家族成员ADAMTS 9，该蛋白具有一个金属蛋白酶结构域、一个去整合素样结构域、一个内部TSP 1基序和三个羧基端TSP 1样亚基序，Tn是对照;相对于其他ADAM-TS家族成员，ADAMTS 9在所有检测的胎儿组织以及一些成人组织中表达。使用FISH和放射杂交分析，我们已经将ADAMTS 9定位于染色体3p14.2-p14.3，这是一个已知在遗传性肾肿瘤中丢失的区域。(C)北京大学出版社.
ADAM-TS/metallospondin genes encode a new family of proteins with structural homology to the ADAM metalloprotease-disintegrin family. However, unlike other ADAMs, these proteins contain thrombospondin type 1 (TSP1) repeats at the carboxy-terminal end and are secreted proteins instead of being membrane bound. Members of the ADAM-TS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis, We have cloned a new member of the ADAM-TS/metallospondin family designated here as ADAMTS9, This protein has a metalloprotease domain, a disintegrin-like domain, one internal TSP1 motif, and three carboxy-terminal TSP1-like submotifs, Tn contrast; to other ADAM-TS family members, ADAMTS9 is expressed in all fetal tissues examined as well as some adult tissues. Using FISH and radiation hybrid analysis, we have localized ADAMTS9 to chromosome 3p14.2-p14.3, an area known to be lost in hereditary renal tumors. (C) 2000 Academic Press.