'Stress' distributions inside intervertebral discs - The effects of age and degeneration
'Stress' distributions inside intervertebral discs - The effects of age and degeneration
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DOI：
10.1302/0301-620x78b6.1287
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发表时间：
1996-11-01
影响因子：
--
通讯作者：
Dolan, P
中科院分区：
文献类型：
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作者：
Adams, MA;McNally, DS;Dolan, P
我们使用安装在直径为1.3 mm的针中的压力传感器研究了尸体椎间盘内的压缩“应力”分布。当椎间盘受到恒定压缩力时，将针沿着腰椎间盘的中矢径拉动，传感器的表面垂直或水平，为了确定每个椎间盘内垂直和水平压应力的分布，对所产生的“应力分布”进行了分析。对年龄在16至87岁之间的受试者的总共87个椎间盘进行了检查，我们的研究结果表明，与年龄相关的退行性改变减少了每个椎间盘中央静水区的直径功能环的宽度增加了80%，其中压缩“应力峰”的高度增加了160%，年龄和退变对L4/L5的影响大于L2/L3，后环受影响大于前环，年龄和退变本身密切相关，但退变阶段对应力分布的影响更大，我们认为，纤维环和终板内的结构变化导致载荷从髓核转移到后纤维环，瓣环内的高“应力”集中可能导致疼痛，并导致进一步的破裂。
We investigated the distribution of compressive 'stress' within cadaver intervertebral discs, using a pressure transducer mounted in a 1.3 mm diameter needle, The needle was pulled along the midsagittal diameter of a lumbar disc with the face of the transducer either vertical or horizontal while the disc was subjected to a constant compressive force, The resulting 'stress profiles' were analysed in order to characterise the distribution of vertical and horizontal compressive stress within each disc, A total of 87 discs from subjects aged between 16 and 87 years was examined,Our results showed that age-related degenerative changes reduced the diameter of the central hydrostatic region of each disc (the 'functional nucleus') by approximately 50%, and the pressure within this region fell by 30%, The width of the functional annulus increased by 80% and the height of compressive 'stress peaks' within it by 160%, The effects of age and degeneration were greater at L4/L5 than at L2/L3, and the posterior annulus was affected more than the anterior, Age and degeneration were themselves closely related, but the stage of degeneration had the greater effect on stress distributions,We suggest that structural changes within the annulus and endplate lead to a transfer of load from the nucleus to the posterior annulus, High 'stress' concentrations within the annulus may cause pain, and lead to further disruption.