The Role of Type VI Collagen in Alveolar Bone.
The Role of Type VI Collagen in Alveolar Bone.
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DOI：
10.3390/ijms232214347
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发表时间：
2022-11-18
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
Many studies have been conducted to elucidate the role of Type VI collagen in muscle and tendon, however, its role in oral tissues remains unclear. In this study, an α2(VI) deficient mouse (Col6α2-KO) model was used to examine the role of Type VI collagen in oral tissues. Tissue volume and mineral density were measured in oral tissues by µCT. Proteome analysis was performed using protein extracted from alveolar bone. In addition, alveolar bone was evaluated with a periodontitis induced model. µCT analysis showed the Col6α2-KO mice had less volume of alveolar bone, dentin and dental pulp, while the width of periodontal ligament (PDL) was greater than WT. The mineral density in alveolar bone and dentin were elevated in Col6α2-KO mice compared with WT. Our proteome analysis showed significant changes in proteins related to ECM organization and elevation of proteins associated with biomineralization in the Col6α2-KO mice. In induced periodontitis, Col6α2-KO mice had greater alveolar bone loss compared with WT. In conclusion, Type VI collagen has a role in controlling biomineralization in alveolar bone and that changes in the ECM of alveolar bone could be associated with greater bone loss due to periodontitis.
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影响因子：
7
作者：
Loeser, RF;Sadiev, S;Goldring, MB
通讯作者：
Goldring, MB
DOI：
10.1007/978-1-62703-989-5_11
发表时间：
2014-01-01
期刊：
SKELETAL DEVELOPMENT AND REPAIR: METHODS AND PROTOCOLS
影响因子：
--
作者：
Kawamoto, Tadafumi;Kawamoto, Komei
通讯作者：
Kawamoto, Komei
影响因子：
2.7
作者：
Goldberg, Michel;Marchadier, Arnaud;Young, Marian
通讯作者：
Young, Marian
影响因子：
7.8
作者：
Stallcup, W B;Dahlin, K;Healy, P
通讯作者：
Healy, P
影响因子：
2.2
作者：
Abe, Toshiharu;Hajishengallis, George
通讯作者：
Hajishengallis, George